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Título

Effect of surface chemistry and associated protein corona on the long-term biodegradation of iron oxide nanoparticles in vivo

AutorStepien, Grazyna; Ruíz del Árbol, María; Pérez-Hernández, Marta CSIC ORCID; Monge, Marta CSIC ORCID; Gutiérrez, Lucía CSIC ORCID; Fratila, Raluca M. CSIC ORCID; Heras, Marcelo de las; Menao, Sebastián; Puente Lanzarote, Juan José; Solans, Conxita CSIC ORCID ; Pardo, Julián; Fuente, Jesús M. de la CSIC ORCID
Palabras claveBiodistribution
In vivo
Iron oxide nanoparticles
Nanoparticles degradation
Protein corona
Fecha de publicación2018
EditorAmerican Chemical Society
CitaciónACS Applied Materials and Interfaces 10(5): 4548-4560 (2018)
ResumenThe protein corona formed on the surface of a nanoparticle in a biological medium determines its behavior in vivo. Herein, iron oxide nanoparticles containing the same core and shell, but bearing two different surface coatings, either glucose or poly(ethylene glycol), were evaluated. The nanoparticles' protein adsorption, in vitro degradation, and in vivo biodistribution and biotransformation over four months were investigated. Although both types of nanoparticles bound similar amounts of proteins in vitro, the differences in the protein corona composition correlated to the nanoparticles biodistribution in vivo. Interestingly, in vitro degradation studies demonstrated faster degradation for nanoparticles functionalized with glucose, whereas the in vivo results were opposite with accelerated biodegradation and clearance of the nanoparticles functionalized with poly(ethylene glycol). Therefore, the variation in the degradation rate observed in vivo could be related not only to the molecules attached to the surface, but also with the associated protein corona, as the key role of the adsorbed proteins on the magnetic core degradation has been demonstrated in vitro.
Versión del editorhttps://doi.org/10.1021/acsami.7b18648
URIhttp://hdl.handle.net/10261/180966
DOI10.1021/acsami.7b18648
ISSN1944-8244
E-ISSN1944-8252
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