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Title: Low-noise polymeric nanomechanical biosensors
Authors: Calleja, Montserrat ; Tamayo de Miguel, Francisco Javier ; Nordström, M.; Boisen, Anja
Keywords: cantilevers
polymers
nanotechnology
microsensors
molecular biophysics
photoresists
passivation
coatings
pH
gold
silicon compounds
biological techniques
Issue Date: 14-May-2006
Publisher: American Institute of Physics
Citation: Applied Physic Letters 88, 113901 (2006)
Abstract: A sensor device based on a single polymer cantilever and optical readout has been developed for detection of molecular recognition reactions without the need of a reference cantilever for subtraction of unspecific signals. Microcantilevers have been fabricated in the photoresist SU-8 with one surface passivated with a thin fluorocarbon layer. The SU-8 surface is sensitized with biological receptors by applying silanization methods, whereas the fluorocarbon surface remains inert to these processes. The thermal and mechanical properties of the chosen materials allow overcoming the main limitations of gold-coated silicon cantilevers: the temperature, pH, and ionic strength cross sensitivities. This is demonstrated by comparing the response of SU-8 cantilevers and that of gold-coated silicon nitride cantilevers to variations in temperature and pH. The sensitivity of the developed polymeric nanomechanical sensor is demonstrated by real-time detection of the human growth hormone with sensitivity in differential surface stress of about 1 mN/m.
Publisher version (URL): http://link.aip.org
http://dx.doi.org/10.1063/1.2187437
URI: http://hdl.handle.net/10261/18075
DOI: 10.1063/1.2187437
ISSN: 0003-6951
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