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Title

Chondroitin Sulfate-Degrading Enzymes as Tools for the Development of New Pharmaceuticals

AuthorsBenito-Arenas, Raúl; Zárate, Sandra G. ; Revuelta, Julia ; Bastida, Agatha
KeywordsIyases
Chondroitin sulfates
Glycosaminoglycan
Polysaccharides
Issue Date1-Apr-2019
PublisherMultidisciplinary Digital Publishing Institute
CitationCatalysts 9(4): 322 (2019)
AbstractChondroitin sulfates are linear anionic sulfated polysaccharides found in biological tissues, mainly within the extracellular matrix, which are degraded and altered by specific lyases depending on specific time points. These polysaccharides have recently acquired relevance in the pharmaceutical industry due to their interesting therapeutic applications. As a consequence, chondroitin sulfate (CS) lyases have been widely investigated as tools for the development of new pharmaceuticals based on these polysaccharides. This review focuses on the major breakthrough represented by chondroitin sulfate-degrading enzymes and their structures and mechanisms of function in addition to their major applications.
Publisher version (URL)http://dx.doi.org/10.3390/catal9040322
URIhttp://hdl.handle.net/10261/180704
DOI10.3390/catal9040322
ISSN2073-4344
Appears in Collections:(ICTP) Artículos
(IQOG) Artículos
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