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http://hdl.handle.net/10261/180546
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Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Campo DC | Valor | Lengua/Idioma |
---|---|---|
dc.contributor.author | Silva, Sonia | es_ES |
dc.contributor.author | Camino, Lola P. | es_ES |
dc.contributor.author | Aguilera, Andrés | es_ES |
dc.date.accessioned | 2019-04-25T10:44:12Z | - |
dc.date.available | 2019-04-25T10:44:12Z | - |
dc.date.issued | 2018-10-23 | - |
dc.identifier.citation | Proceedings of the National Academy of Sciences of the USA 115(43): 11024-11029 (2018) | es_ES |
dc.identifier.issn | 0027-8424 | - |
dc.identifier.uri | http://hdl.handle.net/10261/180546 | - |
dc.description.abstract | R loops are nucleic acid structures comprising an DNA–RNA hybrid and a displaced single-stranded DNA. These structures may occur transiently during transcription, playing essential biological functions. However, persistent R loops may become pathological as they are important drivers of genome instability and have been associated with human diseases. The mitochondrial degradosome is a functionally conserved complex from bacteria to human mitochondria. It is composed of the ATP-dependent RNA and DNA helicase SUV3 and the PNPase ribonuclease, playing a central role in mitochondrial RNA surveillance and degradation. Here we describe a new role for the mitochondrial degradosome in preventing the accumulation of pathological R loops in the mitochondrial DNA, in addition to preventing dsRNA accumulation. Our data indicate that, similar to the molecular mechanisms acting in the nucleus, RNA surveillance mechanisms in the mitochondria are crucial to maintain its genome integrity by counteracting pathological R-loop accumulation. | es_ES |
dc.description.sponsorship | Research was funded by the European Research Council (Grant ERC2014 AdG669898 TARLOOP), the Spanish Ministry of Economy and Competitiveness (Grants BFU2013-42918-P and BFU2016-75058-P), and the European Union (Fondo Europeo de Desarrollo Regional). S.S. was awarded a Juan de la Cierva–Incorporación grant from the Spanish Ministry of Economy, Industry, and Competitiveness during part of this study. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | National Academy of Sciences (U.S.) | es_ES |
dc.relation | info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/BFU2013-42918-P | es_ES |
dc.relation | info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/BFU2016-75058-P | es_ES |
dc.relation.isversionof | Publisher's version | es_ES |
dc.rights | openAccess | es_ES |
dc.subject | Genome instability | es_ES |
dc.subject | Mitochondrial degradosome | es_ES |
dc.subject | R loops | es_ES |
dc.subject | RNA metabolism | es_ES |
dc.subject | Transcription–replication | es_ES |
dc.subject | Conflicts | es_ES |
dc.title | Human mitochondrial degradosome prevents harmful mitochondrial R loops and mitochondrial genome instability | es_ES |
dc.type | artículo | es_ES |
dc.identifier.doi | 10.1073/pnas.1807258115 | - |
dc.description.peerreviewed | Peer reviewed | es_ES |
dc.relation.publisherversion | https://doi.org/10.1073/pnas.1807258115 | es_ES |
dc.identifier.e-issn | 1091-6490 | - |
dc.contributor.funder | European Research Council | es_ES |
dc.contributor.funder | Ministerio de Economía y Competitividad (España) | es_ES |
dc.contributor.funder | European Commission | es_ES |
dc.relation.csic | Sí | es_ES |
oprm.item.hasRevision | no ko 0 false | * |
dc.identifier.funder | http://dx.doi.org/10.13039/501100003329 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100000781 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100000780 | es_ES |
dc.identifier.pmid | 30301808 | - |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.languageiso639-1 | en | - |
item.fulltext | With Fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.cerifentitytype | Publications | - |
item.grantfulltext | open | - |
item.openairetype | artículo | - |
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Human mitochondrial_Silva.pdf | 1,39 MB | Adobe PDF | Visualizar/Abrir |
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