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Analysis of gene expression profiles of CR80, a neuroprotective 1,8-Naphthyridine

AuthorsRamos, Eva; Romero, Alejandro ; Egea, Javier; Marco-Contelles, José ; Pino, Javier del; Ríos, Cristóbal de los
KeywordsNeuroprotective drugs
Gene expression
SH-SY5Y cells
Signaling pathways
Issue Date2018
PublisherFuture Science
CitationFuture Medicinal Chemistry 10: 1289-1300 (2018)
AbstractThe 1,8-naphthyridine CR80 (ethyl 5-amino-2-methyl-6,7,8,9-tetrahydrobenzo[b] [1,8]naphthyridine-3-carboxylate) has shown interesting neuroprotective properties in in vitro and in vivo models of neurodegeneration. In spite of these promising outcomes, the molecular and cellular mechanisms underlying CR80 actions need to be further explored. Materials & methods: We herein report the signal transduction pathways involved in developmental, neuroprotective and stress-activated processes, as well as the gene expression regulation by CR80 in SH-SY5Y neuroblastoma cells. Results: The CR80 exposure upregulated several antioxidant enzymes (HO-1, GSR, SQSTM1, and TRXR1) and anti-apoptotic proteins (Bcl-xL, Bcl-2, P21, and Wnt6). Conclusion: The observed changes in gene expression would afford new insights on the neuroprotective profile of CR80.
Publisher version (URL)http://dx.doi.org/10.4155/fmc-2018-0004
Identifiersdoi: 10.4155/fmc-2018-0004
issn: 1756-8919
e-issn: 1756-8927
Appears in Collections:(IQOG) Artículos
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