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A role for caspase-8 and TRAIL-R2/DR5 in ER-stress induced apoptosis

AuthorsMuñoz-Pinedo, Cristina; López-Rivas, Abelardo
Issue Date2018
PublisherSpringer Nature
CitationCell Death and Differentiation 25: 226 (2018)
AbstractGlab et al.1 examined in a recent paper apoptosis induced by some drivers of endoplasmic reticulum (ER) stress. They conclude that in contrast to a previously published report,2 DR5/ TRAIL-R2 and caspase-8 are universally dispensable in ERstress-induced apoptosis. We argue here that their own data and other published reports indicate that in many models, DR5 and/or caspase-8 are essential players in apoptosis mediated by the unfolded protein response (UPR), upon chronic ER stress.
Publisher version (URL)https://doi.org/10.1038/cdd.2017.155
Appears in Collections:(CABIMER) Artículos
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