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Título: | Pseudo-Wang Handle for the Preparation of Fully Protected Peptides. Synthesis of Liraglutide by Fragment Condensation |
Autor: | Carbajo, Daniel CSIC ORCID; Fransen, Peter Paul K.H.; El-Faham, Ayman; Royo, Miriam CSIC ORCID ; Albericio, Fernando CSIC ORCID | Palabras clave: | Synthesis of Liraglutide Peptides Fragment condensation |
Fecha de publicación: | 14-mar-2019 | Editor: | American Chemical Society | Citación: | Organic Letters 21 (7): 2459-2463 (2019) | Resumen: | A handle for the protection of the C-terminus of peptides after cleaving with low concentration of trifluoroacetic acid (2-4%) is reported. The handle prevents polymerization reactions in the convergent condensation of peptidic fragments. Moreover, it is traceless, being removed during the final deprotection step of the peptide synthesis. This cheap and convenient handle is easily attached to the solid support, causing no disturbance to peptide elongation and thus proving to be useful in the convergent synthesis of long peptides. © 2019 American Chemical Society. | Versión del editor: | https://pubs.acs.org/doi/abs/10.1021/acs.orglett.9b00813?af=R | URI: | http://hdl.handle.net/10261/179976 | DOI: | 10.1021/acs.orglett.9b00813 |
Aparece en las colecciones: | (IQAC) Artículos |
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Fichero | Descripción | Tamaño | Formato | |
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Pseudo-Wang Handle for the Preparation of Fully Protected Peptides.docx | 480,35 kB | Microsoft Word XML | Visualizar/Abrir |
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