English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/179916
Share/Impact:
Statistics
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:

DC FieldValueLanguage
dc.contributor.authorHerrero, Saturninoes_ES
dc.contributor.authorCalvo, Olgaes_ES
dc.contributor.authorGarcía-Moreno, Carmenes_ES
dc.contributor.authorMartín, Estheres_ES
dc.contributor.authorSan Román, José I.es_ES
dc.contributor.authorMartín, Marianoes_ES
dc.contributor.authorGarcía-Talavera, José R.es_ES
dc.contributor.authorCalvo, José J.es_ES
dc.contributor.authorPino, Javier deles_ES
dc.date.accessioned2019-04-11T12:03:30Z-
dc.date.available2019-04-11T12:03:30Z-
dc.date.issued1998-
dc.identifier.citationCalcified Tissue International 62(3): 260-265 (1998)es_ES
dc.identifier.issn0171-967X-
dc.identifier.urihttp://hdl.handle.net/10261/179916-
dc.description.abstractDiabetes and estrogen deficit are known causes of osteopenia, diabetes being associated with a low bone turnover and estrogen deficit with a high bone turnover. In the present work, we studied the effect of combined ovariectomy and diabetes on bone mineral content (BMC) and bone mineral density (BMD) and several bone markers in the rat. Four groups of rats were studied: control (C), ovariectomized (O), diabetic (D), and ovariectomized and diabetic (DO). Twelve weeks after starting the experiments, BMC and BMD of the first six lumbar vertebrae were measured; a bone formation marker (BGP) and a bone resorption marker (free collagen cross-links, PYD) were also analyzed. Diabetic rats showed diminished gain in bone mass, BMC (D: 0.417 +/- 0.028 g, DO: 0.422 +/- 0.020 g) and BMDs (D: 0.171 +/- 0.006 g/cm2, DO: 0.174 +/- 0.006 g/cm2) both being significantly (P < 0.001) lower than those of control (C: BMC 0.727 +/- 0.024 g and BMD 0.258 +/- 0.004 g/cm2) and ovariectomized (O: BMC 0.640 +/- 0.044 g and BMD 0.240 +/- 0.009 g/cm2) groups. Moreover, the BMC and BMD of the C group were significantly (P < 0.05) higher than that of the O group. BGP and PYD levels were significantly (P < 0.01) higher in the O group (BGP: 138.2 +/- 16.8 ng/ml, PYD: 270.2 +/- 17.8 nM/mM) than those found in the control rats (BGP: 44.7 +/- 4.8 ng/ml, PYD: 165.6 +/- 12.5 nM/mM); the D group showed significantly (P < 0.01) lower values (BGP: 27.4 +/- 14.6 ng/ml, PYD: 55.0 +/- 7.4 nM/mM) than those of the control group. The DO group showed similar levels (BGP: 43.4 +/- 5.1 ng/ml, PYD: 146.7 +/- 14.6 nM/mM) to those found in the C group. Although bone marker levels in the O and D groups were in accordance with those expected in these situations, in the DO group the corresponding levels are apparently "normal." Also, the decrease of gain in bone mass observed after combining estrogen deficit and diabetes (DO group) did not seem to be more marked than that caused by diabetes alone.es_ES
dc.description.sponsorshipThis study was partially supported by a grant from the Comisión Interministerial de Ciencia y Tecnología, Spain (SAL 91-0802). The densitometer was generously donated by Rhône-Poulenc-Rorer S.A.es_ES
dc.language.isoenges_ES
dc.publisherSpringeres_ES
dc.rightsclosedAccesses_ES
dc.subjectDiabeteses_ES
dc.subjectOvariectomyes_ES
dc.subjectBone mineral densityes_ES
dc.subjectBone markerses_ES
dc.subjectRates_ES
dc.titleLow bone density with normal bone turnover in ovariectomized and streptozotocin-induced diabetic ratses_ES
dc.typeartículoes_ES
dc.identifier.doi10.1007/s002239900427-
dc.description.peerreviewedPeer reviewedes_ES
dc.identifier.e-issn1432-0827-
dc.contributor.funderComisión Interministerial de Ciencia y Tecnología, CICYT (España)es_ES
dc.contributor.funderRhône-Poulences_ES
dc.relation.csicNoes_ES
oprm.item.hasRevisionno ko 0 false*
dc.identifier.funderhttp://dx.doi.org/10.13039/501100007273es_ES
dc.identifier.pmid9501961-
Appears in Collections:(IBFG) Artículos
Files in This Item:
File Description SizeFormat 
accesoRestringido.pdf59,24 kBAdobe PDFThumbnail
View/Open
Show simple item record
 

Related articles:


WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.