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Mutants of unspecific peroxygenase with high monooxygenase activity and uses thereof

Other TitlesMutantes de la peroxigenasa inespecífica con alta actividad monooxigenasa y sus usos
AuthorsMolina-Espeja, Patricia ; Plou Gasca, Francisco José ; Alcalde Galeote, Miguel ; Gómez de Santos, Patricia
Issue Date18-May-2017
CitationWO2017081355 A1
Abstract[EN] The invention relates to an unspecific peroxygenase of the Agrocybe aegerita fungus, obtained by means of directed molecular evolution in order to facilitate the functional expression thereof in the active, soluble and stable form. The peroxygenase described in the invention exhibits a significant increase in the functional expression thereof, an improved monooxygenase activity and a reduced peroxydase activity, in relation to the monooxygenase and peroxydase activities exhibited by the wild-type unspecific peroxygenase of A. aegerita. The peroxygenase of the invention can be used in chemical processes, including industrial transformations such as the selective oxyfunctionalisation of carbon-hydrogen bonds of various organic compounds.
[ES] La presente invención se refiere a una peroxigenasa inespecífica del hongo Agrocybe aegeritaobtenida mediante evolución molecular dirigida para facilitar su expresión funcional en forma activa, soluble y estable. La peroxigenasa descrita en la presente invención presenta un incremento significativo en su expresión funcional, una actividad monooxigenasa mejorada y una actividad peroxidasa disminuida, respecto a las actividades monooxigenasa y peroxidasa que presenta la peroxigenasa inespecífica silvestre de A. aegerita. La peroxigenasa de la invención es útil en procesos químicos, incluyendo transformaciones industriales como son la oxifuncionalización selectiva de enlaces carbono-hidrógeno de diversos compuestos orgánicos.
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