Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/179072
COMPARTIR / EXPORTAR:
SHARE CORE BASE | |
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Campo DC | Valor | Lengua/Idioma |
---|---|---|
dc.contributor.author | Blasco, Víctor | es_ES |
dc.contributor.author | Pinto Pérez, Francisco M. | es_ES |
dc.contributor.author | Fernández- Atucha, Ainhoa | es_ES |
dc.contributor.author | Prados, Nicolás | es_ES |
dc.contributor.author | Tena-Sempere, Manuel | es_ES |
dc.contributor.author | Fernández-Sánchez, Manuel | es_ES |
dc.contributor.author | Candenas, M. Luz | es_ES |
dc.date.accessioned | 2019-04-02T08:31:57Z | - |
dc.date.available | 2019-04-02T08:31:57Z | - |
dc.date.issued | 2019 | - |
dc.identifier.citation | Journal of Assisted Reproduction and Genetics, 36(1): 113-120 (2019) | es_ES |
dc.identifier.uri | http://hdl.handle.net/10261/179072 | - |
dc.description.abstract | PURPOSE: The neurokinin B (NKB)/NK3 receptor (NK3R) and kisspeptin (KISS1)/kisspeptin receptor (KISS1R), two systems essential for reproduction, are present in human granulosa cells (GCs) of healthy women and contribute to the control of fertility, at least partially, by acting on the gonads. However, little is known about the expression of these systems in GCs of women with polycystic ovarian syndrome (PCOS). The aim of this study was to analyze the expression of NKB/NK3R and KISS1/KISS1R in mural granulosa (MGCs) and cumulus cells (CCs) of PCOS women. METHODS: A cross-sectional study was performed in 46 healthy women and 43 PCOS women undergoing controlled ovarian stimulation. MGCs and CCs were collected from pre-ovulatory follicles after transvaginal ultrasound-guided oocyte retrieval and the expression of the genes encoding NKB (TAC3), NK3R (TACR3), KISS1, and its receptor (KISS1R) was analyzed using real-time quantitative RT-PCR. RESULTS: TAC3, TACR3, and KISS1 mRNA levels were decreased in MGCs and CCs of PCOS women. TAC3 positively correlated with KISS1 in MGCs of healthy women and TACR3 was positively associated with KISS1R in CCs from healthy women. These associations were not observed in PCOS women. CONCLUSION: The NKB/NK3R and KISS1/KISS1R systems are dysregulated in MGCs and CCs of PCOS women. The lower expression of these systems in GCs could contribute to the abnormal follicle development and defective ovulation that characterize the pathogenesis of PCOS. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Springer Nature | es_ES |
dc.relation.isversionof | Postprint | es_ES |
dc.rights | openAccess | en_EN |
dc.subject | Cumulus cells | es_ES |
dc.subject | Granulosa cells | es_ES |
dc.subject | Kisspeptin | es_ES |
dc.subject | Neurokinin B | es_ES |
dc.subject | Polycystic ovarian syndrome | es_ES |
dc.title | Altered expression of the kisspeptin/KISS1R and neurokinin B/NK3R systems in mural granulosa and cumulus cells of patients with polycystic ovarian syndrome | es_ES |
dc.type | artículo | es_ES |
dc.identifier.doi | 10.1007/s10815-018-1338-7 | - |
dc.description.peerreviewed | Peer reviewed | es_ES |
dc.relation.publisherversion | https://doi.org/10.1007/s10815-018-1338-7 | es_ES |
dc.embargo.terms | 2019-10-31 | es_ES |
dc.contributor.funder | Ministerio de Economía y Competitividad (España) | es_ES |
dc.relation.csic | Sí | es_ES |
oprm.item.hasRevision | no ko 0 false | * |
dc.identifier.funder | http://dx.doi.org/10.13039/501100003329 | es_ES |
dc.identifier.pmid | 30382469 | - |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.languageiso639-1 | en | - |
item.fulltext | With Fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.cerifentitytype | Publications | - |
item.grantfulltext | open | - |
item.openairetype | artículo | - |
Aparece en las colecciones: | (IIQ) Artículos |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
2018-NKB-KISSPEPTIN-PCOS-ARTICULO EN FORMATO ENVIADO-JARG-D-18-00500.pdf | 352,26 kB | Adobe PDF | Visualizar/Abrir |
CORE Recommender
PubMed Central
Citations
12
checked on 24-abr-2024
SCOPUSTM
Citations
29
checked on 19-abr-2024
WEB OF SCIENCETM
Citations
25
checked on 26-feb-2024
Page view(s)
249
checked on 23-abr-2024
Download(s)
178
checked on 23-abr-2024
Google ScholarTM
Check
Altmetric
Altmetric
Artículos relacionados:
NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.