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Title

Honeycomb patterned surfaces functionalized with polypeptide sequences for recognition and selective bacterial adhesion

AuthorsSanz, Alberto; Rodríguez Hernández, Juan; Cortajarena, Aitziber L.
KeywordsBacterial adhesion
Molecular recognition
Biomolecular patterning
Honeycomb structures
Polymer surfaces
Breath figures
Issue DateFeb-2013
PublisherElsevier
CitationBiomaterials 34(5): 1453-1460 (2013)
AbstractWe report on the preparation of functional polymer surfaces with controlled topography by using the breath figures approach. The resulting surfaces prepared from a mixture of a PS-b-PAA diblock copolymer and a homopolymer (PS) exhibit pores that are mainly composed of diblock copolymer whereas the rest of the surface is formed by homopolymer. The formation of a hexagonal assembly of pores was achieved by controlling several parameters during the casting process including relative humidity, composition of the blend and polymer concentration. A selective modification of the pore inner part by using appropriate polypeptide sequences permitted the use of these surfaces as scaffolds for pattern and display of active biomolecules, as ordered templates for specific recognition processes and finally for the micropatterning of bacterial cells.
Publisher version (URL)https://doi.org/10.1016/j.biomaterials.2012.10.074
URIhttp://hdl.handle.net/10261/179005
DOI10.1016/j.biomaterials.2012.10.074
ISSN0142-9612
Appears in Collections:(ICTP) Artículos
(CNB) Artículos
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