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Título

Decreased CX3CL1 levels in the cerebrospinal fluid of patients with Alzheimer's disease

AutorPerea, Juan Ramón; Lleó, Alberto; Alcolea, Daniel; Fortea, Juan; Ávila, Jesús CSIC ORCID ; Bolós, Marta CSIC ORCID
Palabras claveInflammation
Human CSF
Microglia
CX3CL1
Alzheimer’s disease
Tau
Fecha de publicación7-sep-2018
CitaciónFrontiers in Neuroscience 12 (2018)
ResumenAlzheimer's disease (AD) is a neurodegenerative disease characterized by the presence of neurofibrillary tangles, constituted by tau protein, and plaques formed by amyloid-beta protein. The disease courses with high neural damage, which leads to memory loss and death. Here we analyzed the presence of CX3CL1, a chemokine expressed by neurons, in cerebrospinal fluid (CSF) samples from control subjects and patients with mild cognitive impairment and AD dementia. CX3CL1 was decreased in the CSF of AD dementia patients compared to control subjects. However, there was not difference in plasma samples from the same subjects.
URIhttp://hdl.handle.net/10261/178876
DOI10.3389/fnins.2018.00609
Identificadoresdoi: 10.3389/fnins.2018.00609
issn: 1662-453X
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