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Título: | Sequential Norrish type II photoelimination and intramolecular aldol cyclization of α-diketones: Synthesis of polyhydroxylated cyclopentitols by ring contraction of hexopyranose carbohydrate derivatives |
Autor: | Álvarez‐Dorta, Dimitri; León, Elisa I. CSIC ORCID ; Kennedy, Alan R.; Martín, Ángeles CSIC ORCID ; Pérez-Martín, Inés CSIC ORCID ; Riesco-Fagundo, Concepción CSIC; Suárez, Ernesto CSIC ORCID | Palabras clave: | Cyclopentitols Diketones Photochemistry Ring Contraction Carbohydrates |
Fecha de publicación: | 20-jun-2013 | Editor: | Wiley-VCH | Citación: | Chemistry - A European Journal 19(31): 10312-10333 (2013) | Resumen: | The excitation of the innermost carbonyl of nono‐2,3‐diulose derivatives by irradiation with visible‐light initiates a sequential Norrish type II photoelimination and aldol cyclization process that finally gives polyfunctionalized cyclopentitols. The rearrangement has been confirmed by the isolation of stable acyclic photoenol intermediates that can be independently cyclized by a thermal 5‐(enolexo)‐exo‐trig uncatalyzed aldol reaction with high diastereoselectivity. In this last step, the large deuterium kinetic isotope effect found for the 1,5‐hydrogen atom transfer seems to indicate that the aldol reaction runs through a concerted pericyclic mechanism. Owing to the ready availability of pyranose sugars of various configurations, this protocol has been used to study the influence of pyranose ring‐substituents on the diastereoselectivity of the aldol cyclization reaction. In contrast with other pyranose ring contraction methodologies no transition‐metal reagents are needed and the sequential rearrangement occurs simply by using visible light and moderate heating (0 to 60 °C). | Versión del editor: | https://doi.org/10.1002/chem.201301230 | URI: | http://hdl.handle.net/10261/178823 | DOI: | 10.1002/chem.201301230 | Identificadores: | doi: 10.1002/chem.201301230 issn: 0947-6539 e-issn: 1521-3765 |
Aparece en las colecciones: | (IPNA) Artículos |
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CEJ 2013, 19, 10312.pdf | Artículo principal | 3,24 MB | Adobe PDF | Visualizar/Abrir |
CEJ 2013, 19, 10312-SI.pdf | Supporting Information | 2,71 MB | Adobe PDF | Visualizar/Abrir |
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