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Título

Early adipose deposits in sheep: comparative analysis of the perirenal fat ranscriptome of Assaf and Churra suckling lambs

AutorSuárez-Vega, Aroa; Arranz, Juan José; Pérez Pérez, Valentín CSIC ORCID ; de la Fuente, L. F.; Mateo, J.; Gutiérrez Gil, Beatriz
Palabras claveRNA-seq
Carcass traits
Gene expression
Sheep
Fecha de publicación2018
EditorBlackwell Publishing
CitaciónAnimal Genetics 49: 605- 617 (2018)
ResumenAdipose deposits influence the quality of ruminant carcasses, and in suckling lambs, internal types of adipose deposits represent a notable proportion of total fat. The aim of this study was to perform a comparative analysis of the perirenal fat transcriptomes of suckling lambs from two breeds with different growth and carcass characteristics. The perirenal fat tissue from 14 suckling lambs (Assaf, n = 8; Churra, n = 6) was used for the RNA-seq analysis. The functional enrichment analysis of the 670 highly expressed genes (>150 fragments per kilobase of exon per million fragments mapped) in the perirenal fat transcriptome of both breeds revealed that the majority of these genes were involved in energy processes. The expression of the UCP1 gene, a classical biomarker of brown fat, and the presence of multilocular adipocytes in the two breeds supported the presence of brown fat at the transition stage towards white fat tissue. The differential expression analysis performed identified 373 differentially expressed genes (DEGs) between the two compared breeds. Brown/white fat gene biomarkers were not included in the list of DEGs. In Assaf lambs, DEGs were enriched in Gene Ontology (GO) biological processes related to fatty-acid oxidation, whereas in Churra lambs, the majority of the significantly enriched GO terms were related to cholesterol synthesis, which suggests that upregulated DEGs in Assaf lambs are implicated in fat burning, whereas the Churra upregulated DEGs are linked to fat accumulation. These results can help to increase knowledge of the genes controlling early fat deposition in ruminants and shed light on fundamental aspects of adipose tissue growth.
Descripción13 páginas, 3 figuras, 2 tablas.
Versión del editorhttp://dx.doi.org/10.1111/age.12725
URIhttp://hdl.handle.net/10261/178796
DOI10.1111/age.12725
ISSN0268-9146
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