English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/178779
Share/Impact:
Statistics
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:

Title

Chemokines cooperate with TNF to provide protective anti-viral immunity and to enhance inflammation

AuthorsAlejo, Alí; Ruiz-Argüello, Maria Begoña; Pontejo, Sergio M.; Fernández de Marco, M. del Mar ; Saraiva, Margarida; Hernáez, Bruno ; Alcamí, Antonio
Issue Date2018
PublisherNature Publishing Group
CitationNature Communications 9 (2018)
AbstractThe role of cytokines and chemokines in anti-viral defense has been demonstrated, but their relative contribution to protective anti-viral responses in vivo is not fully understood. Cytokine response modifier D (CrmD) is a secreted receptor for TNF and lymphotoxin containing the smallpox virus-encoded chemokine receptor (SECRET) domain and is expressed by ectromelia virus, the causative agent of the smallpox-like disease mousepox. Here we show that CrmD is an essential virulence factor that controls natural killer cell activation and allows progression of fatal mousepox, and demonstrate that both SECRET and TNF binding domains are required for full CrmD activity. Vaccination with recombinant CrmD protects animals from lethal mousepox. These results indicate that a specific set of chemokines enhance the inflammatory and protective anti-viral responses mediated by TNF and lymphotoxin, and illustrate how viruses optimize anti-TNF strategies with the addition of a chemokine binding domain as soluble decoy receptors.
URIhttp://hdl.handle.net/10261/178779
Identifiersdoi: 10.1038/s41467-018-04098-8
issn: 2041-1723
Appears in Collections:(CBM) Artículos
Files in This Item:
File Description SizeFormat 
AlcamíA_ChemokinesCooperate.pdf2,07 MBAdobe PDFThumbnail
View/Open
Show full item record
Review this work
 

Related articles:


WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.