English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/178680
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:


Uncovering the potential of novel micromonosporae isolated from an extreme hyper-arid Atacama Desert soil

AuthorsCarro, Lorena ; Franco Castro, Jean; Razmilic, Valeria; Nouioui, Imen; Pan, Che; Igual, José Mariano ; Jaspars, Marsel; Goodfellow, Michael; Bull, Alan T.; Asenjo, Juan A.; Klenk, Hans-Peter
Atacama Desert
Novel micromonosporae
Issue Date2019
PublisherSpringer Nature
CitationScientific Reports 9: 4678 (2019)
AbstractThe taxonomic status, biotechnological and ecological potential of several Micromonospora strains isolated from an extreme hyper arid Atacama Desert soil were determined. Initially, a polyphasic study was undertaken to clarify the taxonomic status of five micromonosporae, strains LB4, LB19, LB32 T , LB39 T and LB41, isolated from an extreme hyper-arid soil collected from one of the driest regions of the Atacama Desert. All of the isolates were found to have chemotaxonomic, cultural and morphological properties consistent with their classification in the genus Micromonospora. Isolates LB32 T and LB39 T were distinguished from their nearest phylogenetic neighbours and proposed as new species, namely as Micromonospora arida sp. nov. and Micromonospora inaquosa sp. nov., respectively. Eluted methanol extracts of all of the isolates showed activity against a panel of bacterial and fungal indicator strains, notably against multi-drug resistant Klebsiella pneumoniae ATCC 700603 while isolates LB4 and LB41 showed pronounced anti-tumour activity against HepG2 cells. Draft genomes generated for the isolates revealed a rich source of novel biosynthetic gene clusters, some of which were unique to individual strains thereby opening up the prospect of selecting especially gifted micromonosporae for natural product discovery. Key stress-related genes detected in the genomes of all of the isolates provided an insight into how micromonosporae adapt to the harsh environmental conditions that prevail in extreme hyper-arid Atacama Desert soils.
Description16 páginas, 5 tablas y 3 figuras
Publisher version (URL)https://doi.org/10.1038/s41598-019-38789-z
Appears in Collections:(IRNASA) Artículos
Files in This Item:
File Description SizeFormat 
uncovering the potential of novel micromonosporae isolated.pdf2,21 MBAdobe PDFThumbnail
Show full item record
Review this work

Related articles:

WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.