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dc.contributor.authorHerranz, Raúles_ES
dc.contributor.authorDíaz-Castillo, Carloses_ES
dc.contributor.authorNguyen, Thiennga P.es_ES
dc.contributor.authorLovato, Ty Anna L.es_ES
dc.contributor.authorCripps, Richard M.es_ES
dc.contributor.authorMarco, Robertoes_ES
dc.identifier.citationGene Expression Patterns 4(4):183-190 (2004)es_ES
dc.description8 p.- 6 fig.- 1 tabes_ES
dc.description.abstractThe success of the genomic sequencing programs allows the discovery of additional family members of genes encoding known functions. This is the case of the Troponin C gene repertoire in Drosophila melanogaster. We have found two new Troponin C genes, DmTpnC41F and DmTpnC25D, increasing to five the total number of Troponin C genes identified in this species. The comparative characterization of the five Troponin C genes in D. melanogaster demonstrates considerable variation in gene structure and expression pattern. Expression of one gene, DmTpnC41F, has a more restricted tissue specificity than the rest of the TpnC genes and, with the chromosomically linked DmTpnC41C, is expressed specifically in the adult thorax. The new gene, DmTpnC25D is expressed during development more broadly than the rest. In adults, it is highly expressed in the adult head. Finally, the other two genes, DmTpnC47D and DmTpnC73F, show a high embryonic/larval expression and in adults are expressed almost exclusively in the abdomens. The functional adaptive changes that may have evolved during the expansion of this gene family are briefly discussed in terms of the expression patterns, gene and protein structures leading to a simpler, more systematic nomenclature of the gene family.es_ES
dc.description.sponsorshipThis research was supported by grants from the Spanish Government PB96-0069, ESP1999-0379-C02 and PNE- 008/2001-C, and by GM61738 awarded by the National Institutes of Health to RMC.es_ES
dc.subjectTroponin complex gene familieses_ES
dc.subjectNew Troponin C geneses_ES
dc.subjectRACE analyseses_ES
dc.subjectDrosophila Melanogaster larval and adult muscleses_ES
dc.subjectExpression Patternses_ES
dc.titleExpression patterns of the whole Troponin C gene repertoire during Drosophila developmentes_ES
dc.description.peerreviewedPeer reviewedes_ES
oprm.item.hasRevisionno ko 0 false*
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