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Título: | GPETAFLR, a novel bioactive peptide from Lupinus angustifolius L. protein hydrolysate, reduces osteoclastogenesis |
Autor: | Millán-Linares, María del Carmen CSIC ORCID ; Lemus-Conejo, Ana CSIC ORCID CVN; Yust, María del Mar CSIC ORCID; Pedroche, Justo CSIC ORCID ; Carrillo-Vico, Antonio CSIC ORCID; Millán, Francisco CSIC ORCID ; Montserrat-de la Paz, Sergio CSIC ORCID | Palabras clave: | Peptide Protein hydrolysate Lupine Osteoclast Osteoporosis |
Fecha de publicación: | ago-2018 | Editor: | Elsevier | Citación: | Journal of Functional Foods 47: 299- 303 (2018) | Resumen: | The effect of GPETAFLR, a peptide isolated from Lupinus angustifolius L. protein hydrolysate (LPH), on osteoclastogenesis was investigated. Human osteoclasts generated from monocytes were used to analyse the effects of GPETAFLR (50–100 µg/mL) on osteoclastogenesis using TRAP reaction, RT-qPCR, and ELISA procedures. LPS enhanced TRAP activity and the expression of osteoclast marker genes (TRAP, OSCAR, RANK, and CATHK) while downregulated the expression of OPG gene in human monocyte-derived osteoclasts. These effects were reduced with GPETAFLR. Moreover, LPS increased the release of osteoclastogenic cytokines (TNF-α, IL-1β, and IL-6) meanwhile GPETAFLR increased the release of anti-osteoclastogenic cytokines (IL-4 and IL-10) in the medium of human monocyte-derived osteoclasts. For the first time, we show that plant peptides from lupine protein hydrolysates have anti-osteoclastogenic activity. These exciting findings open opportunities for developing nutritional strategies with Lupinus angustifolius L. as dietary source of plant proteins, notably GPETAFLR, to prevent development and progression of osteoclast-related diseases. | Descripción: | 20 Páginas.-- 2 Figuras.-- 1 Tabla | Versión del editor: | http://doi.org10.1016/j.jff.2018.05.069 | URI: | http://hdl.handle.net/10261/178457 | DOI: | 10.1016/j.jff.2018.05.069 | Identificadores: | doi: 10.1016/j.jff.2018.05.069 issn: 1756-4646 |
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