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http://hdl.handle.net/10261/178378
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Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Campo DC | Valor | Lengua/Idioma |
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dc.contributor.author | Martínez Álvarez, Óscar | es_ES |
dc.contributor.author | Batista, Irineu | - |
dc.contributor.author | Ramos, Cristina | - |
dc.contributor.author | Montero García, Pilar | - |
dc.date.accessioned | 2019-03-23T23:05:18Z | - |
dc.date.available | 2019-03-23T23:05:18Z | - |
dc.date.issued | 2016 | - |
dc.identifier.citation | Food and Function 7(4): 2066-2073 (2016) | es_ES |
dc.identifier.uri | http://hdl.handle.net/10261/178378 | - |
dc.description.abstract | This work was focused on the study of the bioactive potential of three fish protein hydrolysates, one of them prepared from industrial sardine by-products (heads and viscera) and the others from tuna by-products (heads, and muscle and viscera). These protein hydrolysates exhibited moderate ability to inhibit Angiotensin Converting Enzyme (IC50 between 0.24-1.16 mg dry weight/ml) and Prolyl Oligopeptidase (IC50 between 3.30-9.57 mg/ml), being those obtained from tuna by-products the most effective. Overall, ACE- and PO-inhibiting activities were enhanced by sequential nanofiltration through 3 and 1 kDa MWCO membranes (IC50 between 0.02-0.16 mg/ml (ACE) and 1.10-4.21 mg/ml (PO)). The inhibitory properties of the hydrolysates were greatly improved by in vitro gastric digestion, and were barely affected by further intestinal digestion. The digested tuna hydrolysates proved to be the best source of PO- and ACE- inhibiting molecules (mainly that from heads (IC50 = 0.16 mg/ml (ACE) and 1.04 mg/ml (PO)) and could be potential new ingredients in food with interest in the prevention or treatment of cardiovascular and neurological diseases. | es_ES |
dc.description.sponsorship | This research was financed by EU under the SEAFOODplus European Integrated Programme (Seafoodplus CT-2004-506359), by the Spanish Ministry of Economy and Competitiveness (project AGL2014-52825-R) and also by the Spanish National Research Council (CSIC) under project ref. 200970I113. | - |
dc.language.iso | eng | es_ES |
dc.publisher | Royal Society of Chemistry (UK) | - |
dc.relation | info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/AGL2014-52825-R | es_ES |
dc.relation.isversionof | Postprint | es_ES |
dc.rights | openAccess | es_ES |
dc.subject | Hypertension | es_ES |
dc.subject | Fish waste | es_ES |
dc.subject | Angiotensin converting enzyme | es_ES |
dc.subject | Prolyl oligopeptidase | es_ES |
dc.title | Enhancement of ACE and prolyl oligopeptidase inhibitory potency of protein hydrolysates from sardine and tuna by-products by simulated gastrointestinal digestion | es_ES |
dc.type | artículo | es_ES |
dc.identifier.doi | 10.1039/C5FO01603G | - |
dc.description.peerreviewed | Peer reviewed | es_ES |
dc.relation.publisherversion | https://doi.org/10.1039/C5FO01603G | - |
dc.identifier.e-issn | 2042-650X | - |
dc.contributor.funder | Consejo Superior de Investigaciones Científicas (España) | - |
dc.contributor.funder | Ministerio de Economía y Competitividad (España) | - |
dc.relation.csic | Sí | es_ES |
oprm.item.hasRevision | no ko 0 false | * |
dc.identifier.funder | http://dx.doi.org/10.13039/501100003339 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100003329 | es_ES |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.openairetype | artículo | - |
item.cerifentitytype | Publications | - |
item.languageiso639-1 | en | - |
item.grantfulltext | open | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.fulltext | With Fulltext | - |
Aparece en las colecciones: | (ICTAN) Artículos |
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Fichero | Descripción | Tamaño | Formato | |
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Manuscript accepted Enhancement of ACE... 2016.pdf | 1,32 MB | Adobe PDF | Visualizar/Abrir |
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