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dc.contributor.authorMartínez Álvarez, Óscares_ES
dc.contributor.authorBatista, Irineu-
dc.contributor.authorRamos, Cristina-
dc.contributor.authorMontero García, Pilar-
dc.date.accessioned2019-03-23T23:05:18Z-
dc.date.available2019-03-23T23:05:18Z-
dc.date.issued2016-
dc.identifier.citationFood and Function 7(4): 2066-2073 (2016)es_ES
dc.identifier.urihttp://hdl.handle.net/10261/178378-
dc.description.abstractThis work was focused on the study of the bioactive potential of three fish protein hydrolysates, one of them prepared from industrial sardine by-products (heads and viscera) and the others from tuna by-products (heads, and muscle and viscera). These protein hydrolysates exhibited moderate ability to inhibit Angiotensin Converting Enzyme (IC50 between 0.24-1.16 mg dry weight/ml) and Prolyl Oligopeptidase (IC50 between 3.30-9.57 mg/ml), being those obtained from tuna by-products the most effective. Overall, ACE- and PO-inhibiting activities were enhanced by sequential nanofiltration through 3 and 1 kDa MWCO membranes (IC50 between 0.02-0.16 mg/ml (ACE) and 1.10-4.21 mg/ml (PO)). The inhibitory properties of the hydrolysates were greatly improved by in vitro gastric digestion, and were barely affected by further intestinal digestion. The digested tuna hydrolysates proved to be the best source of PO- and ACE- inhibiting molecules (mainly that from heads (IC50 = 0.16 mg/ml (ACE) and 1.04 mg/ml (PO)) and could be potential new ingredients in food with interest in the prevention or treatment of cardiovascular and neurological diseases.es_ES
dc.description.sponsorshipThis research was financed by EU under the SEAFOODplus European Integrated Programme (Seafoodplus CT-2004-506359), by the Spanish Ministry of Economy and Competitiveness (project AGL2014-52825-R) and also by the Spanish National Research Council (CSIC) under project ref. 200970I113.-
dc.language.isoenges_ES
dc.publisherRoyal Society of Chemistry (UK)-
dc.relationinfo:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/AGL2014-52825-Res_ES
dc.relation.isversionofPostprintes_ES
dc.rightsopenAccesses_ES
dc.subjectHypertensiones_ES
dc.subjectFish wastees_ES
dc.subjectAngiotensin converting enzymees_ES
dc.subjectProlyl oligopeptidasees_ES
dc.titleEnhancement of ACE and prolyl oligopeptidase inhibitory potency of protein hydrolysates from sardine and tuna by-products by simulated gastrointestinal digestiones_ES
dc.typeartículoes_ES
dc.identifier.doi10.1039/C5FO01603G-
dc.description.peerreviewedPeer reviewedes_ES
dc.relation.publisherversionhttps://doi.org/10.1039/C5FO01603G-
dc.identifier.e-issn2042-650X-
dc.contributor.funderConsejo Superior de Investigaciones Científicas (España)-
dc.contributor.funderMinisterio de Economía y Competitividad (España)-
dc.relation.csices_ES
oprm.item.hasRevisionno ko 0 false*
dc.identifier.funderhttp://dx.doi.org/10.13039/501100003339es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/501100003329es_ES
dc.type.coarhttp://purl.org/coar/resource_type/c_6501es_ES
item.openairetypeartículo-
item.cerifentitytypePublications-
item.languageiso639-1en-
item.grantfulltextopen-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.fulltextWith Fulltext-
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