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Ubiquitin-specific protease 26 (USP26) is not essential for mouse gametogenesis and fertility

AuthorsFelipe-Medina, Natalia ; Gomez-H, Laura; Condezo, Yazmine B.; Sánchez-Martín, M.; Barbero, José Luis ; Ramos, Isabel ; Llano, Elena ; Pendás, Alberto M.
Ubiquitin-specific protease
Issue Date18-Mar-2019
CitationChromosoma (2019)
AbstractUbiquitin-specific protease 26 (USP26) is a deubiquitylating enzyme belonging to the USPs family with a transcription patternrestricted to the male germline. Since protein ubiquitination is an essential regulatory mechanism during meiosis, many effortshave been focused on elucidating the function of USP26 and its relationship with fertility. During the last decade, several studieshave reported the presence of different polymorphisms inUSP26in patients with non-obstructive azoospermia (NOA) or severeoligozoospermia suggesting that this gene may be associated with human infertility. However, other studies have revealed thepresence of these and novel polymorphisms, including nonsense mutations, in men with normal spermatogenesis as well. Thus,the results remain controversial and its function is unknown. In the present study, we describe the in vivo functional analysis ofmice lacking USP26. The phenotypic analysis of two differentUsp26-null mutants showed no overt-phenotype with both malesand females being fertile. Cytological analysis of spermatocytes showed no defects in synapsis, chromosome dynamics, DNArepair, or recombination. Histopathological analysis revealed a normal distribution and number of the different cell types in bothmale and female mice. Finally, normal counts were observed in fertility assessments. These results represent the first in vivoevidence showing that USP26 is not essential for mouse gametogenesis.
Description32 p.-5 fig.-1 tab.-2 fig. supl.-6 tab. supl.
Publisher version (URL)https://doi.org/10.1007/s00412-019-00697-6
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(CIB) Artículos
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