Evaluation of the anti-inflammatory potential of an agonistic CD200R1 aptamer on activated glial cultures

Abstract

Neuroinflammation constitutes a fundamental process involved in the progression of several neurodegenerative disorders as well as other neurological diseases. Its study has gained interest since it could help to treat different brain pathologies. The involvement of microglial cells on neuroinflammation has been known for a long time, but its function is not fully understood. CD200-CD200R1 ligand-receptor system has been described as essential for the inhibitory control of the inflammatory response as its signalig can decrease microglial activation. The present work was aimed at reducing microglial activation through the modulation of CD200-CD200R1 signaling pathway. To achieve so, primary mice glial cell cultures were treated with the aptamer molecule M52, which was expected to act as an agonist for CD200R1, and consequently, produce an anti-inflammatory effect.