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Assembly of glycoamino acid building blocks: a new strategy for the straightforward synthesis of heparan sulfate mimics

AuthorsRevuelta, Julia ; Fuentes, Roberto; Lagartera, Laura ; Hernáiz, María J.; Bastida, Agatha; García-Junceda, Eduardo ; Fernández-Mayoralas, Alfonso
Issue Date2018
PublisherRoyal Society of Chemistry
CitationChemical Communications 54: 13455-13458 (2018)
AbstractA new strategy that enables a modular straightforward synthesis of heparan sulfate oligosaccharide mimics by the assembly of simple glycoamino acid building blocks is described. The coupling between units is readily carried out by an amidation reaction. Several glycoamino acid oligomers were prepared and their interaction with the FGF2 protein was analyzed.
DescriptionDedicated to Guillermo Corrales on the occasion of his retirement
Publisher version (URL)http://dx.doi.org/10.1039/c8cc08067d
Identifiersdoi: 10.1039/c8cc08067d
issn: 1359-7345
e-issn: 1364-548X
Appears in Collections:(IQOG) Artículos
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