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| Título: | OptoGluNAM4.1, a Photoswitchable Allosteric Antagonist for Real-Time Control of mGlu4 Receptor Activity |
Autor: | Rovira, Xavier CSIC ORCID; Trapero, Ana CSIC ORCID; Llebaria, Amadeu CSIC ORCID | Palabras clave: | Receptors, Metabotropic Glutamate Schizophrenia mGlu receptor Azobenzene OptoGluNAM4.1 |
Fecha de publicación: | 18-ago-2016 | Editor: | Elsevier | Citación: | Cell Chemical Biology 23 (8): 929-934 (2016) | Resumen: | OptoGluNAM4.1, a negative allosteric modulator (NAM) of metabotropic glutamate receptor 4 (mGlu4) contains a reactive group that covalently binds to the receptor and a blue-light-activated, fast-relaxing azobenzene group that allows reversible receptor activity photocontrol in vitro and in vivo. OptoGluNAM4.1 induces light-dependent behavior in zebrafish and reverses the activity of the mGlu4 agonist LSP4-2022 in a mice model of chronic pain, defining a photopharmacological tool to better elucidate the physiological roles of the mGlu4 receptor in the nervous system. © 2016 Elsevier Ltd | URI: | http://hdl.handle.net/10261/177707 | DOI: | 10.1016/j.chembiol.2016.06.013 |
| Aparece en las colecciones: | (IQAC) Artículos |
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| Fichero | Descripción | Tamaño | Formato | |
|---|---|---|---|---|
| OptoGluNAM4.1, a Photoswitchable Allosteric.pdf | 1,84 MB | Adobe PDF |  Visualizar/Abrir |
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