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Título: | Longitudinal monitoring of anti-saliva antibodies as markers of repellent efficacy against Phlebotomus perniciosus and Phlebotomus papatasi in dogs |
Autor: | Risueño, José; Spitzová, T; Bernal, Luis J.; Muñoz, Clara; López López, Manuel Carlos; Thomas, María del Carmen; Infante, J. J.; Volf, P.; Berriatua, Eduardo | Palabras clave: | Antibodies Antigens Dogs Insecticides Saliva Sandfly |
Fecha de publicación: | mar-2019 | Editor: | John Wiley & Sons | Citación: | Medical and Veterinary Entomology | Resumen: | A 2-year longitudinal study of enzyme-linked immunosorbent assay (ELISA) antibodies against Phlebotomus perniciosus and Phlebotomus papatasi (Diptera: Psychodidae) sandfly saliva was performed in 32 Beagle dogs treated preventively with an imidacloprid-permethrin topical insecticide in an endemic area in Spain. Dogs were grouped into three sandfly exposure groups according to the time of inclusion in the study. Assays analysed immunoglobulin G (IgG) against salivary gland homogenates (SGH) of both species and recombinant P. papatasi rSP32 and P. perniciosus rSP03B proteins in serum. The dogs were participating in a Leishmania infantum (Kinetoplastida: Trypanosomatidae) vaccine trial and were experimentally infected with the parasite in the second year. No dog acquired natural L. infantum infections during the first year, but most developed anti-saliva antibodies, and median log-transformed optical densities (LODs) were seasonal, mimicking those of local sandflies. This indicates that the repellent efficacy of the insecticide used is below 100%. Multi-level modelling of LODs revealed variability among dogs, autocorrelation and differences according to the salivary antigen and the dog's age. However, dog seroprevalence, estimated using pre-exposure LODs as cut-offs, was relatively low. This, and the fact that dogs did not become naturally infected with L. infantum, would support the efficacy and usefulness of this imidacloprid-permethrin topical insecticide in canine leishmaniasis control. | URI: | http://hdl.handle.net/10261/177560 | DOI: | 10.1111/mve.12343 | ISSN: | 0269-283X | E-ISSN: | 1365-2915 |
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