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Title

Intraarterial route increases the risk of cerebral lesions after mesenchymal cell administration in animal model of ischemia

AuthorsArgibay, Bárbara; Trekker, Jesse; Himmelreich, Uwe; Beiras, Andrés; Topete, Antonio; Taboada, Pablo; Pérez-Mato, María; Vieites-Prado, Alba; Iglesias-Rey, Ramón; Rivas, José; Planas, Anna M. ; Sobrino, Tomás; Castillo, José; Campos, Francisco
Issue Date16-Jan-2017
PublisherNature Publishing Group
CitationScientific Reports 7: 40758 (2017)
AbstractMesenchymal stem cells (MSCs) are a promising clinical therapy for ischemic stroke. However, critical parameters, such as the most effective administration route, remain unclear. Intravenous (i.v.) and intraarterial (i.a.) delivery routes have yielded varied outcomes across studies, potentially due to the unknown MSCs distribution. We investigated whether MSCs reached the brain following i.a. or i.v. administration after transient cerebral ischemia in rats, and evaluated the therapeutic effects of both routes. MSCs were labeled with dextran-coated superparamagnetic nanoparticles for magnetic resonance imaging (MRI) cell tracking, transmission electron microscopy and immunohistological analysis. MSCs were found in the brain following i.a. but not i.v. administration. However, the i.a. route increased the risk of cerebral lesions and did not improve functional recovery. The i.v. delivery is safe but MCS do not reach the brain tissue, implying that treatment benefits observed for this route are not attributable to brain MCS engrafting after stroke.
Publisher version (URL)https://doi.org/10.1038/srep40758
URIhttp://hdl.handle.net/10261/177223
DOI10.1038/srep40758
E-ISSN2045-2322
Appears in Collections:(IIBB) Artículos
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