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Title

Rainbow trout (Oncorhynchus mykiss) immune response towards a recombinant vaccine targeting the parasitic ciliate Ichthyophthirius multifiliis

Authorsvon Gersdorff Jørgensen, Louise; Kania, P. W.; Rasmussen, K. J.; Mattsson, A. H.; Schmidt, J.; Al‐Jubury, A.; Sander, A.; Salanti, A.; Buchmann, A.
KeywordsParasite Ichthyophthirius multifiliis
Rainbow trout
Subunit vaccine
Vaccine
Issue DateDec-2017
PublisherWiley-Blackwell
CitationJournal of Fish Diseases 40(12): 1815-1821 (2017)
AbstractThe protective effect in rainbow trout (Oncorhynchus mykiss) of an experimental subunit vaccine targeting antigens in the parasite Ichthyophthirius multifiliis has been evaluated and compared to effects elicited by a classical parasite homogenate vaccine. Three recombinant parasite proteins (two produced in E. coli and one in insect cells) were combined and injected i.p., and subsequently, protection and antibody responses were analysed. Both the experimental and the benchmark vaccine induced partial but significant protection against I. multifiliis when compared to control fish. Specific antibody responses of vaccinated trout (subunit vaccine) were raised against one neurohypophysial n‐terminal domain protein #10 of three recombinant proteins, whereas the benchmark vaccine group showed specific antibody production against all three recombinant proteins. The immunogenic parasite protein #10 may be a potential vaccine candidate supplementing the protective I‐antigen in future vaccine trials.
DescriptionParaFishControl is coordinated by Spanish National Research Council (CSIC).
Publisher version (URL)https://doi.org/10.1111/jfd.12653
URIhttp://hdl.handle.net/10261/177214
DOI10.1111/jfd.12653
ISSN0140-7775
E-ISSN1365-2761
Appears in Collections:(IATS) Artículos
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