English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/177214
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:

Rainbow trout (Oncorhynchus mykiss) immune response towards a recombinant vaccine targeting the parasitic ciliate Ichthyophthirius multifiliis

Authorsvon Gersdorff Jørgensen, Louise; Kania, P. W.; Rasmussen, K. J.; Mattsson, A. H.; Schmidt, J.; Al‐Jubury, A.; Sander, A.; Salanti, A.; Buchmann, A.
KeywordsParasite Ichthyophthirius multifiliis
Rainbow trout
Subunit vaccine
Issue DateDec-2017
CitationJournal of Fish Diseases 40(12): 1815-1821 (2017)
AbstractThe protective effect in rainbow trout (Oncorhynchus mykiss) of an experimental subunit vaccine targeting antigens in the parasite Ichthyophthirius multifiliis has been evaluated and compared to effects elicited by a classical parasite homogenate vaccine. Three recombinant parasite proteins (two produced in E. coli and one in insect cells) were combined and injected i.p., and subsequently, protection and antibody responses were analysed. Both the experimental and the benchmark vaccine induced partial but significant protection against I. multifiliis when compared to control fish. Specific antibody responses of vaccinated trout (subunit vaccine) were raised against one neurohypophysial n‐terminal domain protein #10 of three recombinant proteins, whereas the benchmark vaccine group showed specific antibody production against all three recombinant proteins. The immunogenic parasite protein #10 may be a potential vaccine candidate supplementing the protective I‐antigen in future vaccine trials.
DescriptionParaFishControl is coordinated by Spanish National Research Council (CSIC).
Publisher version (URL)https://doi.org/10.1111/jfd.12653
Appears in Collections:(IATS) Artículos
Files in This Item:
File Description SizeFormat 
Rainbow_Trout_manuscript.pdf280,55 kBAdobe PDFThumbnail
Show full item record
Review this work

Related articles:

WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.