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dc.contributor.authorLeal, Estheres_ES
dc.contributor.authorZarza, Carleses_ES
dc.contributor.authorTafalla, Carolinaes_ES
dc.date.accessioned2019-03-05T07:52:54Z-
dc.date.available2019-03-05T07:52:54Z-
dc.date.issued2017-08-
dc.identifier.citationFish & Shellfish Immunology 67: 179-188 (2017)es_ES
dc.identifier.issn1050-4648-
dc.identifier.urihttp://hdl.handle.net/10261/177209-
dc.descriptionParaFishControl is coordinated by Spanish National Research Council (CSIC).es_ES
dc.description.abstractVitamin C, also known as ascorbic acid, is an essential micronutrient that influences a wide variety of physiological processes, including immunological functions. Although the positive effects of vitamin C supplementation on the immunological status of fish has been established in different species, the bases for these positive effects are still unknown. Hence, the aim of our study was to evaluate the in vitro effect of vitamin C on several innate immune functions of rainbow trout (Oncorhynchus mykiss) leukocyte populations. For this, we assessed the effects exerted on the established rainbow trout monocyte-macrophage cell line RTS11, and compared them to those observed in trout head kidney leukocytes. Our results demonstrate that vitamin C increases the production of reactive oxygen species and the percentage of phagocytic cells in both cell populations. On the other hand, vitamin C had no effect on the surface MHC II levels and only in the case of RTS11 cells increased the capacity of these cells to migrate towards the CK9 chemokine. Finally, vitamin C also increased the transcription of several pro-inflammatory and antimicrobial genes elicited by Escherichia coli, with some differences depending on the cell population studied. Our results contribute to further understand how vitamin C supplementation regulates the fish immune system.es_ES
dc.description.sponsorshipThis work was supported by the European Commission under the Horizon H2020 research and innovation programme (Grant H2020-634429 ParaFishControl).es_ES
dc.language.isoenges_ES
dc.publisherElsevieres_ES
dc.relationinfo:eu-repo/grantAgreement/EC/H2020/634429es_ES
dc.relation.isversionofPostprint-
dc.rightsopenAccesses_ES
dc.subjectVitamin Ces_ES
dc.subjectRainbow troutes_ES
dc.subjectRTS11 cellses_ES
dc.subjectHead kidney leukocyteses_ES
dc.subjectPhagocytosises_ES
dc.subjectRespiratory burstes_ES
dc.subjectAntibacterial activitieses_ES
dc.titleEffect of vitamin C on innate immune responses of rainbow trout (Oncorhynchus mykiss) leukocyteses_ES
dc.typeartículoes_ES
dc.identifier.doi10.1016/j.fsi.2017.06.021-
dc.description.peerreviewedPeer reviewedes_ES
dc.relation.publisherversionhttps://doi.org/10.1016/j.fsi.2017.06.021es_ES
dc.identifier.e-issn1095-9947-
dc.contributor.funderEuropean Commissiones_ES
dc.relation.csicNoes_ES
oprm.item.hasRevisionno ko 0 false*
dc.identifier.funderhttp://dx.doi.org/10.13039/501100000780es_ES
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