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The Future of TB Resistance Diagnosis: The Essentials on Whole Genome Sequencing and Rapid Testing Methods

AuthorsMoreno-Molina, Miguel; Comas, Iñaki ; Furió, Victoria
KeywordsMycobacterium tuberculosis
Antibiotic resistance
Whole genome sequencing
Precision medicine
Rapid diagnostics
Issue Date19-Feb-2019
CitationArchivos de Bronconeumologia 55(8):421-426 (2019)
AbstractTuberculosis resistance diagnostics have vastly improved in recent years thanks to the development of standardised phenotypic and molecular testing methods. However, these methods are either slow or limited in the number of resistant genotypes they can detect. With the advent of next-generation sequencing (NGS) we can sidestep all those problems, as we can sequence whole tuberculosis genomes at increasingly smaller costs and requiring less and less DNA. In this review, we explain how accumulated knowledge in the field has allowed us to go from phenotypic testing to molecular methods to Whole Genome Sequencing (WGS) for resistance diagnostics. We compare current diagnostic methods with WGS as to their efficacy in detecting resistant cases, and show how forthcoming advances in NGS technologies will be crucial in widespread implementation of WGS as a diagnostic tool.
Description6 páginas, 1 tabla 1 figura
Publisher version (URL)http://dx.doi.org/10.1016/j.arbres.2019.01.002
Appears in Collections:(IBV) Artículos
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