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dc.contributor.authorBlanco, Igores_ES
dc.contributor.authorZirak, Peymanes_ES
dc.contributor.authorDragojević, Tanjaes_ES
dc.contributor.authorCastellví, Claraes_ES
dc.contributor.authorDurduran, Turgutes_ES
dc.contributor.authorJusticia, Carleses_ES
dc.date.accessioned2019-03-01T13:57:21Z-
dc.date.available2019-03-01T13:57:21Z-
dc.date.issued2017-12-
dc.identifier.citationNeurophotonic 4(4): 045006 (2017)es_ES
dc.identifier.urihttp://hdl.handle.net/10261/177106-
dc.description.abstractNeural activity is an important biomarker for the presence of neurodegenerative diseases, cerebrovascular alterations, and brain trauma; furthermore, it is a surrogate marker for treatment effects. These pathologies may occur and evolve in a long time-period, thus, noninvasive, transcutaneous techniques are necessary to allow a longitudinal follow-up. In the present work, we have customized noninvasive, transcutaneous, diffuse correlation spectroscopy (DCS) to localize changes in cerebral blood flow (CBF) induced by neural activity. We were able to detect changes in CBF in the somatosensory cortex by using a model of electrical forepaw stimulation in rats. The suitability of DCS measurements for longitudinal monitoring was demonstrated by performing multiple sessions with the same animals at different ages (from 6 to 18 months). In addition, functional DCS has been cross-validated by comparison with functional magnetic resonance imaging (fMRI) in the same animals in a subset of the time-points. The overall results obtained with transcutaneous DCS demonstrates that it can be utilized in longitudinal studies safely and reproducibly to locate changes in CBF induced by neural activity in the small animal brain.es_ES
dc.description.sponsorshipThe project was funded by Fundació CELLEX Barcelona, Ministerio de Economía y Competitividad (PHOTODEMENTIA, DPI2015-64358-C2-1-R and DPI2015-64358-C2-2-R, PHOTOSTROKE), the “Severo Ochoa” Programme for Centres of Excellence in R&D (SEV-2015-0522), the Obra social “la Caixa” Foundation (LlumMedBcn), Instituto de Salud Carlos III / FEDER (Medphotage, DTS16/00087), AGAURGeneralitat (2014-SGR725, 2014SGR-1555), LaserLab-Europe IV. We are indebted to the Experimental MRI 7T Unit of the IDIBAPS for the technical help.es_ES
dc.language.isoenges_ES
dc.publisherThe International Society for Optics and Photonicses_ES
dc.relationinfo:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/DPI2015-64358-C2-1-Res_ES
dc.relationinfo:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/DPI2015-64358-C2-2-Res_ES
dc.relationinfo:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/SEV-2015-0522es_ES
dc.relation.isversionofPublisher's versiones_ES
dc.rightsopenAccesses_ES
dc.subjectBlood or tissue constituent monitoringes_ES
dc.subjectFunctional monitoring and imaginges_ES
dc.subjectSpectroscopyes_ES
dc.subjectSpecklees_ES
dc.titleLongitudinal, transcranial measurement of functional activation in the rat brain by diffuse correlation spectroscopyes_ES
dc.typeartículoes_ES
dc.identifier.doi10.1117/1.NPh.4.4.045006-
dc.description.peerreviewedPeer reviewedes_ES
dc.relation.publisherversionhttps://doi.org/10.1117/1.NPh.4.4.045006es_ES
dc.identifier.e-issn2329-4248-
dc.rights.licensehttps://creativecommons.org/licenses/by/3.0/es_ES
dc.contributor.funderFundació Privada Cellexes_ES
dc.contributor.funderMinisterio de Economía y Competitividad (España)es_ES
dc.contributor.funderFundación la Caixaes_ES
dc.contributor.funderInstituto de Salud Carlos IIIes_ES
dc.contributor.funderEuropean Commissiones_ES
dc.relation.csices_ES
oprm.item.hasRevisionno ko 0 false*
dc.identifier.funderhttp://dx.doi.org/10.13039/501100000780es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/501100004587es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/501100003329es_ES
dc.identifier.pmid29226175-
dc.type.coarhttp://purl.org/coar/resource_type/c_6501es_ES
item.openairetypeartículo-
item.cerifentitytypePublications-
item.languageiso639-1en-
item.grantfulltextopen-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.fulltextWith Fulltext-
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