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Campo DC | Valor | Lengua/Idioma |
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dc.contributor.author | Llopis, Silvia | - |
dc.contributor.author | Rodrigo, María Jesús | - |
dc.contributor.author | González, Nuria | - |
dc.contributor.author | Genovés, Salvador | - |
dc.contributor.author | Zacarías, Lorenzo | - |
dc.contributor.author | Ramón, Daniel | - |
dc.contributor.author | Martorell Guerola, Patricia | - |
dc.date.accessioned | 2019-03-01T10:49:36Z | - |
dc.date.available | 2019-03-01T10:49:36Z | - |
dc.date.issued | 2019-01-22 | - |
dc.identifier.citation | Nutrients 11(2): 232 (2019) | - |
dc.identifier.issn | 2072-6643 | - |
dc.identifier.uri | http://hdl.handle.net/10261/177052 | - |
dc.description.abstract | β-Cryptoxanthin (BCX) is a major dietary pro-vitamin A carotenoid, found mainly in fruits and vegetables. Several studies showed the beneficial effects of BCX on different aspects of human health. In spite of the evidence, the molecular mechanisms of action of BCX need to be further investigated. The <i>Caenorhabditis elegans</i> model was used to analyze in vivo the activity of BCX on fat reduction and protection to oxidative stress. Dose-response assays provided evidence of the efficacy of BCX at very low dose (0.025 µg/mL) (<i>p</i> < 0.001) on these processes. Moreover, a comparative analysis with other carotenoids, such as lycopene and β-carotene, showed a stronger effect of BCX. Furthermore, a transcriptomic analysis of wild-type nematodes supplemented with BCX revealed upregulation of the energy metabolism, response to stress, and protein homeostasis as the main metabolic targets of this xanthophyll. Collectively, this study provides new in vivo evidence of the potential therapeutic use of BCX in the prevention of diseases related to metabolic syndrome and aging. | - |
dc.description.sponsorship | This study has been funded by the Spanish Ministry of Economy and Competitiveness (MINECO), Consolider Fun-C-Food (CSD 2007-00063 project), and AGL2015-70218. M.J.R. and L.Z. belong to the Spanish Carotenoid Network (CaRed) funded by the Spanish MINECO grant BIO2015-71703-REDT and BIO2017-90877-REDT, and the European Carotenoid Network (EuroCaroten) funded by the European Commission COST action CA15136. We thank to the UCIM at University of Valencia for performing the DNA arrays. | - |
dc.description.sponsorship | We acknowledge support by the CSIC Open Access Publication Initiative through its Unit of Information Resources for Research (URICI) | - |
dc.publisher | Multidisciplinary Digital Publishing Institute | - |
dc.relation | info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/AGL2015-70218-R | - |
dc.relation | info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/BIO2015-71703-REDT | - |
dc.relation | info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/BIO2017-90877-REDT | - |
dc.relation.isversionof | Publisher's version | - |
dc.rights | openAccess | - |
dc.subject | β-Cryptoxanthin | - |
dc.subject | Carotenoids | - |
dc.subject | Caenorhabditis elegans | - |
dc.subject | Fat reduction | - |
dc.subject | Oxidative stress | - |
dc.subject | Transcriptomic analysis | - |
dc.subject | Metabolic syndrome | - |
dc.subject | Aging | - |
dc.title | β-Cryptoxanthin Reduces Body Fat and Increases Oxidative Stress Response in Caenorhabditis elegans Model | - |
dc.type | artículo | - |
dc.identifier.doi | 10.3390/nu11020232 | - |
dc.description.peerreviewed | Peer reviewed | - |
dc.relation.publisherversion | http://dx.doi.org/10.3390/nu11020232 | - |
dc.date.updated | 2019-03-01T10:49:36Z | - |
dc.rights.license | http://creativecommons.org/licenses/by-nc-sa/4.0/ | - |
dc.contributor.funder | Consejo Superior de Investigaciones Científicas (España) | - |
dc.contributor.funder | Ministerio de Economía y Competitividad (España) | - |
dc.contributor.funder | European Cooperation in Science and Technology | - |
dc.relation.csic | Sí | - |
dc.identifier.funder | http://dx.doi.org/10.13039/501100003339 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100000921 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100003329 | es_ES |
dc.identifier.pmid | 30678209 | - |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.openairetype | artículo | - |
item.grantfulltext | open | - |
item.cerifentitytype | Publications | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.fulltext | With Fulltext | - |
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nutrients-11-00232.pdf | 4,92 MB | Adobe PDF | Visualizar/Abrir |
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