English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/177052
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:

β-Cryptoxanthin Reduces Body Fat and Increases Oxidative Stress Response in Caenorhabditis elegans Model

AuthorsLlopis, Silvia ; Rodrigo, María Jesús ; González, Nuria; Genovés, Salvador; Zacarías, Lorenzo ; Ramón, Daniel ; Martorell Guerola, Patricia
Caenorhabditis elegans
Fat reduction
Oxidative stress
Transcriptomic analysis
Metabolic syndrome
Issue Date22-Jan-2019
PublisherMultidisciplinary Digital Publishing Institute
CitationNutrients 11(2): 232 (2019)
Abstractβ-Cryptoxanthin (BCX) is a major dietary pro-vitamin A carotenoid, found mainly in fruits and vegetables. Several studies showed the beneficial effects of BCX on different aspects of human health. In spite of the evidence, the molecular mechanisms of action of BCX need to be further investigated. The <i>Caenorhabditis elegans</i> model was used to analyze in vivo the activity of BCX on fat reduction and protection to oxidative stress. Dose-response assays provided evidence of the efficacy of BCX at very low dose (0.025 µg/mL) (<i>p</i> < 0.001) on these processes. Moreover, a comparative analysis with other carotenoids, such as lycopene and β-carotene, showed a stronger effect of BCX. Furthermore, a transcriptomic analysis of wild-type nematodes supplemented with BCX revealed upregulation of the energy metabolism, response to stress, and protein homeostasis as the main metabolic targets of this xanthophyll. Collectively, this study provides new in vivo evidence of the potential therapeutic use of BCX in the prevention of diseases related to metabolic syndrome and aging.
Publisher version (URL)http://dx.doi.org/10.3390/nu11020232
Appears in Collections:(IATA) Artículos
Files in This Item:
File Description SizeFormat 
nutrients-11-00232.pdf4,92 MBAdobe PDFThumbnail
Show full item record
Review this work

Related articles:

WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.