English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/176957
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:


Unambiguous detection of atherosclerosis using bioorthogonal nanomaterials

AuthorsPellico, Juan; Fernández-Barahona, Irene; Benito, Marina; Gaitán-Simón, Ángel; Gutiérrez, Lucía ; Ruiz-Cabello, Jesús; Herranz, Fernando
KeywordsMolecular imaging
Iron oxide
Issue Date2019
CitationNanomedicine: Nanotechnology, Biology, and Medicine 17: 26-35 (2019)
AbstractThe importance of atherosclerosis is driving research to create improved diagnostic tools based on molecular imaging. Pretargeted imaging is the use of bioorthogonal probes that selectively accumulate upon reaction with a pre-modified biomolecule in vivo. To date, this very promising approach has not been applied to atherosclerosis. Neither has been the use of a single nano-radiomaterial for PET / T-MR imaging of atherosclerosis. Here, we synthesized bioorthogonal nano-radiomaterials for in vivo pretargeted molecular imaging in a mouse model of atherosclerosis. Based on tetrazine-ligation, these functionalized Ga iron oxide nano-radiomaterials provide simultaneous PET and T-MRI signals and selectively accumulate in atherosclerotic plaques in mice sequentially injected with trans-cyclooctene-modified antibodies against oxidized LDL followed by the hybrid nano-radiomaterial. Our results demonstrate the ability of this approach to unambiguously detect atherosclerosis. Furthermore, we show the first example of how hybrid imaging can be used for pretargeted bioorthogonal molecular imaging with nanomaterials.
Publisher version (URL)http://dx.doi.org/10.1016/j.nano.2018.12.015
Identifiersdoi: 10.1016/j.nano.2018.12.015
issn: 1549-9642
Appears in Collections:(ICMA) Artículos
(IQM) Artículos
Files in This Item:
File Description SizeFormat 
unambigunano.pdf797,73 kBAdobe PDFThumbnail
Show full item record
Review this work

Related articles:

WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.