Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/176896
COMPARTIR / EXPORTAR:
SHARE CORE BASE | |
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Título: | SIRT1 overexpression in mouse hippocampus induces cognitive enhancement through proteostatic and neurotrophic mechanisms |
Autor: | Corpas, Rubén CSIC ORCID; Revilla, Susana CSIC; Ursulet, Suzanna; Castro, Marco; Kaliman, Perla CSIC; Petegnief, Valérie CSIC ORCID; Giménez-Llort, Lydia; Sarkis Chamsy; Pallàs, Mercè; Sanfeliu, Coral CSIC ORCID | Palabras clave: | SIRT1 3xTg-AD mice Cognitive enhancement Proteasome Insulin-degrading enzyme Glial cell line-derived neurotrophic factor (GDNF) |
Fecha de publicación: | sep-2017 | Editor: | Springer Nature | Citación: | Molecular Neurobiology 54(7): 5604-5619 (2017) | Resumen: | SIRT1 induces cell survival and has shown neuroprotection against amyloid and tau pathologies in Alzheimer’s disease (AD). However, protective effects against memory loss or the enhancement of cognitive functions have not yet been proven. We aimed to investigate the benefits induced by SIRT1 overexpression in the hippocampus of the AD mouse model 3xTg-AD and in control non-transgenic mice. A lentiviral vector encoding mouse SIRT1 or GFP, selectively transducing neurons, was injected into the dorsal CA1 hippocampal area of 4-month-old mice. Six-month overexpression of SIRT1 fully preserved learning and memory in 10-month-old 3xTg-AD mice. Remarkably, SIRT1 also induced cognitive enhancement in healthy non-transgenic mice. Neuron cultures of 3xTg-AD mice, which show traits of AD-like pathology, and neuron cultures from non-transgenic mice were also transduced with lentiviral vectors to analyze beneficial SIRT1 mechanisms. We uncovered novel pathways of SIRT1 neuroprotection through enhancement of cell proteostatic mechanisms and activation of neurotrophic factors not previously reported such as GDNF, present in both AD-like and healthy neurons. Therefore, SIRT1 may increase neuron function and resilience against AD. | Versión del editor: | https://doi.org/10.1007/s12035-016-0087-9 | URI: | http://hdl.handle.net/10261/176896 | DOI: | 10.1007/s12035-016-0087-9 | ISSN: | 0893-7648 | E-ISSN: | 1559-1182 |
Aparece en las colecciones: | (IIBB) Artículos |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
accesoRestringido.pdf | 15,38 kB | Adobe PDF | Visualizar/Abrir |
CORE Recommender
SCOPUSTM
Citations
87
checked on 20-abr-2024
WEB OF SCIENCETM
Citations
76
checked on 26-feb-2024
Page view(s)
165
checked on 23-abr-2024
Download(s)
19
checked on 23-abr-2024
Google ScholarTM
Check
Altmetric
Altmetric
NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.