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Bone morphogenetic protein-9/activin-like kinase 1 axis a new target for hepatic regeneration and fibrosis treatment in liver injury

AuthorsMarí, Montserrat ; Morales, Albert
Issue DateDec-2017
PublisherAME Publishing
CitationHepatobiliary surgery and nutrition 6(6): 414-416 (2017)
AbstractBone morphogenetic protein-9 (BMP-9), a member of the transforming growth factor (TGF)-β family of cytokines, is preferentially expressed in the liver from where is secreted into the blood (1-3). BMP-9 and BMP-10 are high-affinity ligands for the type I receptor activin-like kinase 1 (ALK1), whose participation in liver fibrosis has been previously suggested, and activin type II receptor A (ActRIIA) a BMP type II receptor with undefined role in liver biology. Although BMP-9 promotes epithelial to mesenchymal transition in hepatocellular carcinoma (HCC) cells, correlating with HCC aggressiveness in patients, and the BMP-9/ALK1 signaling has been related to liver pathologies, little was known about BMP-9 specific functions in liver cells and, particularly, after hepatic injury.
Publisher version (URL)http://dx.doi.org/10.21037/hbsn.2017.11.02
Appears in Collections:(IIBB) Artículos
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