English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/176462
Share/Impact:
Statistics
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:

Title

Environmental enrichment improves cognitive deficits, AD hallmarks and epigenetic alterations presented in 5xFAD mouse model

AuthorsGriñán-Ferré, Christian; Izquierdo, Vanesa; Otero, Eduard; Puigoriol-Illamola, Dolors; Corpas, Rubén ; Sanfeliu, Coral ; Ortuño-Sahagún, Daniel; Pallàs, Mercè
KeywordsBehavior
Cognition,
Environmental enrichment
Epigenetics
APP
Tau
Oxidative stress
Inflammation
Issue Date15-Aug-2018
PublisherFrontiers Media
CitationFrontiers in Cellular Neuroscience 12: 224 (2018)
AbstractCumulative evidence shows that modifications in lifestyle factors constitute an effective strategy to modulate molecular events related to neurodegenerative diseases, confirming the relevant role of epigenetics. Accordingly, Environmental Enrichment (EE) represents an approach to ameliorate cognitive decline and neuroprotection in Alzheimer’s disease (AD). AD is characterized by specific neuropathological hallmarks, such as β-amyloid plaques and Neurofibrillary Tangles, which severely affect the areas of the brain responsible for learning and memory. We evaluated EE neuroprotective influence on 5xFAD mice. We found a better cognitive performance on EE vs. Control (Ct) 5xFAD mice, until being similar to Wild-Type (Wt) mice group. Neurodegenerative markers as β-CTF and tau hyperphosphorylation, reduced protein levels whiles APPα, postsynaptic density 95 (PSD95) and synaptophysin (SYN) protein levels increased protein levels in the hippocampus of 5xFAD-EE mice group. Furthermore, a reduction in gene expression of Il-6, Gfap, Hmox1 and Aox1 was determined. However, no changes were found in the gene expression of neurotrophins, such as Brain-derived neurotrophic factor (Bdnf), Nerve growth factor (Ngf), Tumor growth factor (Tgf) and Nerve growth factor inducible (Vgf) in mice with EE. Specifically, we found a reduced DNA-methylation level (5-mC) and an increased hydroxymethylation level (5-hmC), as well as an increased histone H3 and H4 acetylation level. Likewise, we found changes in the hippocampal gene expression of some chromatin-modifying enzyme, such as Dnmt3a/b, Hdac1, and Tet2. Extensive molecular analysis revealed a correlation between neuronal function and changes in epigenetic marks after EE that explain the cognitive improvement in 5xFAD.
Publisher version (URL)https://doi.org/10.3389/fncel.2018.00224
URIhttp://hdl.handle.net/10261/176462
DOI10.3389/fncel.2018.00224
ISSN1662-5102
Appears in Collections:(IIBB) Artículos
Files in This Item:
File Description SizeFormat 
Environmental_GriñanFerre.pdf2,77 MBAdobe PDFThumbnail
View/Open
Show full item record
Review this work
 

Related articles:


WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.