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Downregulated microRNAs in the colorectal cancer: diagnostic and therapeutic perspectives

AutorHernández, Rosa; Sánchez-Jiménez, Ester; Melguizo, Consolación; Prados, Jose; Rama, Ana Rosa
Palabras claveBiomarkers
Colorectal cancer
Diagnosis
miRNA
Therapeutic target
Fecha de publicación30-nov-2018
EditorKorean Society for Biochemistry and Molecular Biology
CitaciónBMB Reports 51(11): 563-571 (2018)
ResumenColorectal cancer (CRC), the third most common cancer in the world, has no specific biomarkers that facilitate its diagnosis and subsequent treatment. The miRNAs, small single-stranded RNAs that repress the mRNA translation and trigger the mRNA degradation, show aberrant levels in the CRC, by which these molecules have been related with the initiation, progression, and drug-resistance of this cancer type. Numerous studies show the microRNAs influence the cellular mechanisms related to the cell cycle, differentiation, apoptosis, and migration of the cancer cells through the post-transcriptionally regulated gene expression. Specific patterns of the upregulated and down-regulated miRNA have been associated with the CRC diagnosis, prognosis, and therapeutic response. Concretely, the downregulated miRNAs represent attractive candidates, not only for the CRC diagnosis, but for the targeted therapies via the tumor-suppressing microRNA replacement. This review shows a general overview of the potential uses of the miRNAs in the CRC diagnosis, prognosis, and treatment with a special focus on the downregulated ones.
Versión del editorhttps://doi.org/10.5483/BMBRep.2018.51.11.116
URIhttp://hdl.handle.net/10261/176159
DOI10.5483/BMBRep.2018.51.11.116
ISSN1976-670X
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