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dc.contributor.authorAmunts, Alexeyes_ES
dc.contributor.authorBrown, Alanes_ES
dc.contributor.authorBai, Xiao-chenes_ES
dc.contributor.authorLlácer, José Luises_ES
dc.contributor.authorHussain, Tanweeres_ES
dc.contributor.authorEmsley, Paules_ES
dc.contributor.authorLong, Feies_ES
dc.contributor.authorMurshudov, Garibes_ES
dc.contributor.authorScheres, Sjors H.W.es_ES
dc.contributor.authorRamakrishnan, V.es_ES
dc.date.accessioned2019-02-14T15:38:03Z-
dc.date.available2019-02-14T15:38:03Z-
dc.date.issued2014-03-28-
dc.identifier.citationScience - AAAS - Incl Science Now - for ABM Norwegian Consortia only - Internet 343(6178):1485-1489 (2014)es_ES
dc.identifier.issn0036-8075-
dc.identifier.urihttp://hdl.handle.net/10261/176132-
dc.description6 páginas, 6 figuras. Contiete material suplementarioes_ES
dc.description.abstractMitochondria have specialized ribosomes that have diverged from their bacterial and cytoplasmic counterparts. We have solved the structure of the yeast mitoribosomal large subunit using single-particle cryo-electron microscopy. The resolution of 3.2 angstroms enabled a nearly complete atomic model to be built de novo and refined, including 39 proteins, 13 of which are unique to mitochondria, as well as expansion segments of mitoribosomal RNA. The structure reveals a new exit tunnel path and architecture, unique elements of the E site, and a putative membrane docking site.es_ES
dc.description.sponsorshipThis work was funded by grants from the UK Medical Research Council (MC_U105184332 to VR, MC_UP_A025_1013 to SHWS and MC_UP_A025_1012 to GM); a Wellcome Trust Senior Investigator award (WT096570), the Agouron Institute and the Jeantet Foundation (VR); fellowships from Human Frontiers Science Programme (AA), EU FP7 Marie Curie (XB), FEBS (JLL), and EMBO (TH). Cryo-EM density maps have been deposited with the EMDB (accession number EMD-2566) and coordinates have been deposited with the PDB (entry code 3J6B).es_ES
dc.language.isoenges_ES
dc.publisherAmerican Association for the Advancement of Sciencees_ES
dc.relation.isversionofPostprintes_ES
dc.rightsopenAccesses_ES
dc.titleStructure of the yeast mitochondrial large ribosomal subunites_ES
dc.typeartículoes_ES
dc.identifier.doi10.1126/science.1249410-
dc.description.peerreviewedPeer reviewedes_ES
dc.relation.publisherversionhttp://dx.doi.org/10.1126/science.1249410es_ES
dc.identifier.e-issn1095-9203-
dc.contributor.funderMedical Research Council (UK)es_ES
dc.contributor.funderAgouron Institutees_ES
dc.contributor.funderLouis Jeantet Foundationes_ES
dc.contributor.funderEuropean Research Counciles_ES
dc.contributor.funderHuman Frontier Science Programes_ES
dc.contributor.funderFederation of European Biochemical Societieses_ES
dc.relation.csicNoes_ES
oprm.item.hasRevisionno ko 0 false*
dc.identifier.funderhttp://dx.doi.org/10.13039/501100000781es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/501100000265es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/100009344es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/100004412es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/100012623es_ES
dc.contributor.orcidLlácer, José Luis [0000-0001-5304-1795]es_ES
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