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http://hdl.handle.net/10261/175993
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Campo DC | Valor | Lengua/Idioma |
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dc.contributor.author | Pino, Javier del | - |
dc.contributor.author | Marco-Contelles, José | - |
dc.contributor.author | López-Muñoz, Francisco | - |
dc.contributor.author | Romero Jódar, Alejandro | - |
dc.contributor.author | Ramos, Eva | - |
dc.date.accessioned | 2019-02-13T12:22:26Z | - |
dc.date.available | 2019-02-13T12:22:26Z | - |
dc.date.issued | 2018 | - |
dc.identifier | doi: 10.1021/acschemneuro.8b00203 | - |
dc.identifier | issn: 1948-7193 | - |
dc.identifier | e-issn: 1948-7193 | - |
dc.identifier.citation | ACS Chemical Neuroscience 9: 2880- 2885 (2018) | - |
dc.identifier.uri | http://hdl.handle.net/10261/175993 | - |
dc.description.abstract | There is clear evidence that neuroinflammation plays a crucial role in the pathogenesis of Alzheimer's disease. Consequently, modulating the inflammatory environment in brain has become a powerful and attractive strategy to deal with Alzheimer's disease physiopathology. In spite of the neuroprotective capacity shown by ASS234, a multitarget propargylamine targeted for Alzheimer's disease, its regulation of inflammation in the brain still remains unexplored. Therefore, we aimed to characterize possible anti-inflammatory effects of ASS234, counteracting induced inflammatory effects in RAW 264.7 cells and evaluating seven neuroinflammation related genes expression profiling (IL-6, IL-10, IL1β, NF-κB, TNF-α, TNFR1, and TGF-β), after ASS234 (5 μM) treatment in SH-SY5Y cells. The analysis of the obtained fold changes lead us to conclude that ASS234 may play an important role facing the neuroinflammatory environment in Alzheimer's disease pathology. | - |
dc.description.sponsorship | J.M.-C. is indebted to MINECO for Grants SAF2012-33304 and SAF2015-65586-R. The authors thank Camilo José Cela University [Project 2015-21 (HISCHEMAO)] for its continued support. | - |
dc.publisher | American Chemical Society | - |
dc.relation | info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/SAF2012-33304 | - |
dc.relation | info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/SAF2015-65586-R | - |
dc.rights | closedAccess | - |
dc.title | Neuroinflammation Signaling Modulated by ASS234, a Multitarget Small Molecule for Alzheimer's Disease Therapy | - |
dc.type | artículo | - |
dc.identifier.doi | 10.1021/acschemneuro.8b00203 | - |
dc.relation.publisherversion | http://dx.doi.org/10.1021/acschemneuro.8b00203 | - |
dc.date.updated | 2019-02-13T12:22:26Z | - |
dc.description.version | Peer Reviewed | - |
dc.language.rfc3066 | eng | - |
dc.contributor.funder | Ministerio de Economía, Industria y Competitividad (España) | - |
dc.contributor.funder | Universidad Camilo José Cela | - |
dc.relation.csic | Sí | - |
dc.identifier.funder | http://dx.doi.org/10.13039/501100010198 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100008742 | es_ES |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.fulltext | No Fulltext | - |
item.cerifentitytype | Publications | - |
item.openairetype | artículo | - |
item.grantfulltext | none | - |
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