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Eubacterium limosum Activates Isoxanthohumol from Hops (Humulus lupulus L.) into the Potent Phytoestrogen 8-Prenylnaringenin In Vitro and in Rat Intestine1–3
|Authors:||Possemiers, Sam; Rabot, Sylvie; Espín de Gea, Juan Carlos ; Bruneau, Aurélia; Philippe, Catherine; González-Sarrías, Antonio ; Heyerick, Arne; Tomás Barberán, Francisco ; Keukeleire, Denis de; Verstraete, Willy|
Humulus lupulus L.
|Publisher:||American Society for Nutrition|
|Citation:||Journal of Nutrition 138: 1310-1316 (2008)|
|Abstract:||Recently, it was shown that the exposure to the potent hop phytoestrogen 8-prenylnaringenin (8-PN) depends on intestinal bacterial activation of isoxanthohumol (IX), but this occurs in only one-third of tested individuals. As the butyrate-producing Eubacterium limosum can produce 8-PN from IX, a probiotic strategy was applied to investigate whether 8-PN production could be increased in low 8-PN producers, thus balancing phytoestrogen exposure. Using fecal samples from high (Hop +) and low (Hop –) 8-PN–producing individuals, a Hop + and Hop – dynamic intestinal model was developed. In parallel, Hop + and Hop – human microbiota-associated rats were developed, germ-free (GF) rats acting as negative controls. IX and then IX + E. limosum were administered in the intestinal model and to the rats, and changes in 8-PN production and exposure were assessed. After dosing IX, 80% was converted into 8-PN in the Hop + model and highest 8-PN production, plasma concentrations, and urinary and fecal excretion occurred in the Hop + rats. Administration of the bacterium triggered 8-PN production in the GF rats and increased 8-PN production in the Hop – model and Hop – rats. 8-PN excretion was similar in the feces (294.1 ± 132.2 nmol/d) and urine (8.5 ± 1.1 nmol/d ) of all rats (n = 18). In addition, butyrate production increased in all rats. In conclusion, intestinal microbiota determined 8-PN production and exposure after IX intake. Moreover, E. limosum administration increased 8-PN production in low producers, resulting in similar 8-PN production in all rats.|
|Description:||7 pages, 2 figures, 4 tables.|
|Publisher version (URL):||http://jn.nutrition.org/cgi/content/abstract/138/7/1310?maxtoshow=&HITS=10&hits=10&RESULTFORMAT=1&andorexacttitle=and&andorexacttitleabs=and&andorexactfulltext=and&searchid=1&FIRSTINDEX=0&sortspec=relevance&firstpage=1310&resourcetype=HWCIT|
|Appears in Collections:||(CEBAS) Artículos|
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