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dc.contributor.authorKamal, Khaled Y.es_ES
dc.contributor.authorvan Loon, Jack JWAes_ES
dc.contributor.authorMedina, F. Javieres_ES
dc.contributor.authorHerranz, Raúles_ES
dc.date.accessioned2019-02-04T13:16:56Z-
dc.date.available2019-02-04T13:16:56Z-
dc.date.issued2019-01-11-
dc.identifier.citationGenomics S0888-7543(18)30536-6 (2019)es_ES
dc.identifier.issn0888-7543-
dc.identifier.urihttp://hdl.handle.net/10261/175188-
dc.description31 p.-5 fig.-2 tab.-2 fig. supl.es_ES
dc.description.abstractPlant cell proliferation is affected by microgravity during spaceflight, but involved molecular mechanisms, key for space agronomy goals, remain unclear. To investigate transcriptomic changes in cell cycle phases caused by simulated microgravity, an Arabidopsis immobilized synchronous suspension culture was incubated in a Random Positioning Machine. After simulation, a transcriptomic analysis was performed with two subpopulations of cells (G2/M and G1 phases enriched) and an asynchronous culture sample. Differential expression was found at cell proliferation, energy/redox and stress responses, plus unknown biological processes gene ontology groups. Overall expression inhibition was a common response to simulated microgravity, but differences peak at the G2/M phase and stress response components change dramatically from G2/M to the G1 subpopulation suggesting a differential adaptation response to simulated microgravity through the cell cycle. Cell cycle adaptation using both known stress mechanisms and unknown function genes may cope with reduced gravity as an evolutionary novel environment.es_ES
dc.description.sponsorshipThis work was supported by the Spanish “Plan Estatal de Investigación Científica y Técnica y de Innovación” of the Ministry of Economy, Industry and Competitiveness [to F.J.M., Grant numbers AYA2012-33982 and ESP2015-64323-R, co-funded by ERDF], by a pre-doctoral fellowship from CSIC, Spain [to K.Y.K., JAE-PreDoc Program, Ref. JAEPre_2010_01894], the ESA-ELIPS Program [to R.H., ESA GIA Project, contract number 4000105761], and ESA support [to J.v.L., via contract TEC-MMG/2012/263 and 4000107455/12/NL/PA].es_ES
dc.language.isoenges_ES
dc.publisherElsevieres_ES
dc.relationMINECO/ICTI2013-2016/AYA2012-33982es_ES
dc.relationMINECO/ICTI2013-2016/ESP2015-64323-Res_ES
dc.relation.isversionofPostprintes_ES
dc.rightsembargoedAccesses_ES
dc.subjectPlantes_ES
dc.subjectCell proliferationes_ES
dc.subjectCell growthes_ES
dc.subjectSimulated microgravityes_ES
dc.subjectSpaceflightes_ES
dc.subjectMicroarrayes_ES
dc.titleDifferential transcriptional profile through cell cycle progression in Arabidopsis cultures under simulated microgravityes_ES
dc.typeartículoes_ES
dc.identifier.doi10.1016/j.ygeno.2019.01.007-
dc.description.peerreviewedPeer reviewedes_ES
dc.relation.publisherversionhttps://doi.org/10.1016/j.ygeno.2019.01.007es_ES
dc.identifier.e-issn1089-8646-
dc.embargo.terms2020-01-11es_ES
dc.contributor.funderMinisterio de Economía, Industria y Competitividad (España)es_ES
dc.relation.csices_ES
oprm.item.hasRevisionno ko 0 false*
dc.identifier.funderhttp://dx.doi.org/10.13039/501100010198es_ES
dc.contributor.orcidKamal, Khaled Y. [0000-0002-6909-8056]es_ES
dc.contributor.orcidvan Loon, Jack JWA [0000-0001-9051-6016]es_ES
dc.contributor.orcidMedina, F. Javier [0000-0002-0866-7710]es_ES
dc.contributor.orcidHerranz, Raúl [0000-0002-0246-9449]es_ES
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