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Título: | Combined assessment of DYRK1A, BDNF and homocysteine levels as diagnostic marker for Alzheimer’s disease |
Autor: | Janel, Nathalie; Alexopoulos, P.; Badel, A.; Lamari, F.; Camproux, A. C.; Lagarde, J.; Simon, S.; Feraudet-Tarisse, C.; Lamourette, P.; Arbones, Maria L. CSIC ORCID ; Paul, J. L.; Dubois, B.; Potier, Marie-Claude; Sarazin, M.; Delabar, Jean M. | Fecha de publicación: | 20-jun-2017 | Editor: | Springer Nature | Citación: | Translational Psychiatry 7: e1154 (2017) | Resumen: | Early identification of Alzheimer’s disease (AD) risk factors would aid development of interventions to delay the onset of dementia, but current biomarkers are invasive and/or costly to assess. Validated plasma biomarkers would circumvent these challenges. We previously identified the kinase DYRK1A in plasma. To validate DYRK1A as a biomarker for AD diagnosis, we assessed the levels of DYRK1A and the related markers brain-derived neurotrophic factor (BDNF) and homocysteine in two unrelated AD patient cohorts with age-matched controls. Receiver-operating characteristic curves and logistic regression analyses showed that combined assessment of DYRK1A, BDNF and homocysteine has a sensitivity of 0.952, a specificity of 0.889 and an accuracy of 0.933 in testing for AD. The blood levels of these markers provide a diagnosis assessment profile. Combined assessment of these three markers outperforms most of the previous markers and could become a useful substitute to the current panel of AD biomarkers. These results associate a decreased level of DYRK1A with AD and challenge the use of DYRK1A inhibitors in peripheral tissues as treatment. These measures will be useful for diagnosis purposes. | Versión del editor: | https://doi.org/10.1038/tp.2017.123 | URI: | http://hdl.handle.net/10261/174711 | DOI: | 10.1038/tp.2017.123 | E-ISSN: | 2158-3188 |
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