English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/174658
Share/Impact:
Statistics
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE
Exportar a otros formatos:

Title

E proteins sharpen neurogenesis by modulating proneural bHLH transcription factors’ activity in an E-box-dependent manner

AuthorsDréau, G. le ; Escalona, René; Fueyo, Raquel; Herrera, Antonio ; Martínez, Juan D. ; Usieto, Susana ; Menendez, Anghara ; Pons, Sebastián ; Martínez-Balbás, Marian ; Martí, Elisa
Issue Date10-Aug-2018
PublishereLife Sciences Publications
CitationeLife 7: e37267 (2018)
AbstractClass II HLH proteins heterodimerize with class I HLH/E proteins to regulate transcription. Here, we show that E proteins sharpen neurogenesis by adjusting the neurogenic strength of the distinct proneural proteins. We find that inhibiting BMP signaling or its target ID2 in the chick embryo spinal cord, impairs the neuronal production from progenitors expressing ATOH1/ASCL1, but less severely that from progenitors expressing NEUROG1/2/PTF1a. We show this context-dependent response to result from the differential modulation of proneural proteins’ activity by E proteins. E proteins synergize with proneural proteins when acting on CAGSTG motifs, thereby facilitating the activity of ASCL1/ATOH1 which preferentially bind to such motifs. Conversely, E proteins restrict the neurogenic strength of NEUROG1/2 by directly inhibiting their preferential binding to CADATG motifs. Since we find this mechanism to be conserved in corticogenesis, we propose this differential co-operation of E proteins with proneural proteins as a novel though general feature of their mechanism of action.
URIhttp://hdl.handle.net/10261/174658
DOI10.7554/eLife.37267
E-ISSN2050-084X
Appears in Collections:(IBMB) Artículos
Files in This Item:
File Description SizeFormat 
E proteins_Dreau.pdf9,83 MBAdobe PDFThumbnail
View/Open
Show full item record
Review this work
 

Related articles:


WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.