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dc.contributor.authorBarrecheguren, Pablo Josées_ES
dc.contributor.authorRos, Orioles_ES
dc.contributor.authorCotrufo, Tizianaes_ES
dc.contributor.authorKunz, Beates_ES
dc.contributor.authorSoriano, Eduardoes_ES
dc.contributor.authorUlloa, Faustoes_ES
dc.contributor.authorStoeckli, Esther T.es_ES
dc.contributor.authorAraújo, Sofia J.es_ES
dc.date.accessioned2019-01-23T10:44:48Z-
dc.date.available2019-01-23T10:44:48Z-
dc.date.issued2017-08-
dc.identifier.citationDevelopmental Neurobiology 77(8): 963-974 (2017)es_ES
dc.identifier.issn1932-8451-
dc.identifier.urihttp://hdl.handle.net/10261/174586-
dc.description.abstractAxonal growth and guidance rely on correct growth cone responses to guidance cues, both in the central nervous system (CNS) and in the periphery. Unlike the signaling cascades that link axonal growth to cytoskeletal dynamics, little is known about the cross‐talk mechanisms between guidance and membrane dynamics and turnover in the axon. Our studies have shown that Netrin‐1/deleted in colorectal cancer signaling triggers exocytosis through the SNARE Syntaxin‐1 (STX‐1) during the formation of commissural pathways. However, limited in vivo evidence is available about the role of SNARE proteins in motor axonal guidance. Here we show that loss‐of‐function of SNARE complex members results in motor axon guidance defects in fly and chick embryos. Knock‐down of Syntaxin‐1, VAMP‐2, and SNAP‐25 leads to abnormalities in the motor axon routes out of the CNS. Our data point to an evolutionarily conserved role of the SNARE complex proteins in motor axon guidance, thereby pinpointing an important function of SNARE proteins in axonal navigation in vivo.es_ES
dc.description.sponsorship-Ramón y Cajal Programme . Grant Numbers: RYC‐2007‐00417 , RYC‐2009‐05510 -Ministerio de Educacion y Ciencia . Grant Number: AP2005‐1662 -IRB Barcelona‐la Caixa fellowship -Spanish MINECO . Grant Numbers: SAF2013‐42445R , BFU2010‐21507 -CIBERNED -Swiss National Foundationes_ES
dc.language.isoenges_ES
dc.publisherJohn Wiley & Sonses_ES
dc.relationMINECO/ICTI2013-2016/SAF2013‐42445-Res_ES
dc.rightsclosedAccesses_ES
dc.subjectAxon guidancees_ES
dc.subjectMotor axones_ES
dc.subjectSyntaxin‐1es_ES
dc.subjectSNARE proteinses_ES
dc.subjectDrosophilaes_ES
dc.titleSNARE proteins play a role in motor axon guidance in vertebrates and invertebrateses_ES
dc.typeartículoes_ES
dc.identifier.doi10.1002/dneu.22481-
dc.description.peerreviewedPeer reviewedes_ES
dc.relation.publisherversionhttp://dx.doi.org/10.1002/dneu.22481es_ES
dc.identifier.e-issn1932-846X-
dc.contributor.funderMinisterio de Educación y Ciencia (España)es_ES
dc.contributor.funderMinisterio de Economía y Competitividad (España)es_ES
dc.contributor.funderInstitute for Research in Biomedicine (Spain)es_ES
dc.contributor.funderObra Social la Caixaes_ES
dc.contributor.funderCentro Investigación Biomédica en Red Enfermedades Neurodegenerativas (España)es_ES
dc.contributor.funderSwiss National Science Foundationes_ES
dc.relation.csices_ES
oprm.item.hasRevisionno ko 0 false*
dc.identifier.funderhttp://dx.doi.org/10.13039/501100003329es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/100007678es_ES
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