English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/17439
Share/Impact:
Statistics
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:

Title

Engineering and Applications of fungal laccases for organic synthesis

AuthorsKunamneni, Adinarayana ; Camarero, Susana ; García-Burgos, Carlos ; Plou Gasca, Francisco José ; Ballesteros Olmo, Antonio ; Alcalde Galeote, Miguel
KeywordsLaccases
EC 1.10.3.2
Issue Date20-Nov-2008
PublisherBioMed Central
CitationMicrobial Cell Factories 7:32 (2008)
AbstractLaccases are multi-copper containing oxidases (EC 1.10.3.2), widely distributed in fungi, higher plants and bacteria. Laccase catalyses the oxidation of phenols, polyphenols and anilines by one-electron abstraction, with the concomitant reduction of oxygen to water in a four-electron transfer process. In the presence of small redox mediators, laccase offers a broader repertory of oxidations including non-phenolic substrates. Hence, fungal laccases are considered as ideal green catalysts of great biotechnological impact due to their few requirements (they only require air, and they produce water as the only by-product) and their broad substrate specificity, including direct bioelectrocatalysis. Thus, laccases and/or laccase-mediator systems find potential applications in bioremediation, paper pulp bleaching, finishing of textiles, bio-fuel cells and more. Significantly, laccases can be used in organic synthesis, as they can perform exquisite transformations ranging from the oxidation of functional groups to the heteromolecular coupling for production of new antibiotics derivatives, or the catalysis of key steps in the synthesis of complex natural products. In this review, the application of fungal laccases and their engineering by rational design and directed evolution for organic synthesis purposes are discussed.
Description17 pages, 9 figures, 2 tables.
Publisher version (URL)http://dx.doi.org/10.1186/1475-2859-7-32
URIhttp://hdl.handle.net/10261/17439
DOI10.1186/1475-2859-7-32
ISSN1475-2589
Appears in Collections:(ICP) Artículos
(CIB) Artículos
Files in This Item:
File Description SizeFormat 
1475-2859-7-32.pdf1,43 MBAdobe PDFThumbnail
View/Open
Show full item record
Review this work
 

Related articles:


WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.