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Título

Polarized cortical tension drives zebrafish epiboly movements

AutorHernández-Vega, Amayra CSIC ORCID; Marsal, María CSIC ORCID; Pouille, Philippe‐Alexandre CSIC; Tosi, Sébastien; Colombelli, Julien; Luque, Tomás; Navajas, Daniel; Pagonabarraga, Ignacio; Martín‐Blanco, Enrique
Palabras claveEpiboly
Hydrodynamics
Mechanics
Morphogenesis
Zebrafish
Fecha de publicación4-ene-2017
EditorEuropean Molecular Biology Organization
CitaciónEMBO Journal 36(1): 25-41 (2017)
ResumenThe principles underlying the biomechanics of morphogenesis are largely unknown. Epiboly is an essential embryonic event in which three tissues coordinate to direct the expansion of the blastoderm. How and where forces are generated during epiboly, and how these are globally coupled remains elusive. Here we developed a method, hydrodynamic regression (HR), to infer 3D pressure fields, mechanical power, and cortical surface tension profiles. HR is based on velocity measurements retrieved from 2D+T microscopy and their hydrodynamic modeling. We applied HR to identify biomechanically active structures and changes in cortex local tension during epiboly in zebrafish. Based on our results, we propose a novel physical description for epiboly, where tissue movements are directed by a polarized gradient of cortical tension. We found that this gradient relies on local contractile forces at the cortex, differences in elastic properties between cortex components and the passive transmission of forces within the yolk cell. All in all, our work identifies a novel way to physically regulate concerted cellular movements that might be instrumental for the mechanical control of many morphogenetic processes.
Versión del editorhttps://doi.org/10.15252/embj.201694264
URIhttp://hdl.handle.net/10261/174244
DOI10.15252/embj.201694264
ISSN0261-4189
E-ISSN1460-2075
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