English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/174244
Share/Impact:
Statistics
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:

Title

Polarized cortical tension drives zebrafish epiboly movements

AuthorsHernández-Vega, Amayra ; Marsal, María; Pouille, Philippe‐Alexandre; Tosi, Sébastien; Colombelli, Julien; Luque, Tomás; Navajas, Daniel; Pagonabarraga, Ignacio; Martín‐Blanco, Enrique
KeywordsEpiboly
Hydrodynamics
Mechanics
Morphogenesis
Zebrafish
Issue Date4-Jan-2017
PublisherEuropean Molecular Biology Organization
CitationEMBO Journal 36(1): 25-41 (2017)
AbstractThe principles underlying the biomechanics of morphogenesis are largely unknown. Epiboly is an essential embryonic event in which three tissues coordinate to direct the expansion of the blastoderm. How and where forces are generated during epiboly, and how these are globally coupled remains elusive. Here we developed a method, hydrodynamic regression (HR), to infer 3D pressure fields, mechanical power, and cortical surface tension profiles. HR is based on velocity measurements retrieved from 2D+T microscopy and their hydrodynamic modeling. We applied HR to identify biomechanically active structures and changes in cortex local tension during epiboly in zebrafish. Based on our results, we propose a novel physical description for epiboly, where tissue movements are directed by a polarized gradient of cortical tension. We found that this gradient relies on local contractile forces at the cortex, differences in elastic properties between cortex components and the passive transmission of forces within the yolk cell. All in all, our work identifies a novel way to physically regulate concerted cellular movements that might be instrumental for the mechanical control of many morphogenetic processes.
Publisher version (URL)https://doi.org/10.15252/embj.201694264
URIhttp://hdl.handle.net/10261/174244
DOI10.15252/embj.201694264
ISSN0261-4189
E-ISSN1460-2075
Appears in Collections:(IBMB) Artículos
Files in This Item:
File Description SizeFormat 
accesoRestringido.pdf15,38 kBAdobe PDFThumbnail
View/Open
Show full item record
Review this work
 

Related articles:


WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.