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Por favor, use este identificador para citar o enlazar a este item: http://hdl.handle.net/10261/17414
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dc.contributor.authorCruz-González, Ignacio-
dc.contributor.authorGonzález-Sarmiento, Rogelio-
dc.date.accessioned2009-10-02T13:54:07Z-
dc.date.available2009-10-02T13:54:07Z-
dc.date.issued2009-08-04-
dc.identifier.citationBMC Cardiovascular Disorders 9: 35 (2009)en_US
dc.identifier.issn1471-2261-
dc.identifier.urihttp://hdl.handle.net/10261/17414-
dc.description6 páginas, 3 tablas.-- This is an Open Access article distributed under the terms of the Creative Commons Attribution License.-- et al.-
dc.description.abstract[Background]: It is estimated that 5% of the hypertensive patients are resistant to conventional antihypertensive therapy. Polymorphisms in the endothelial nitric oxide synthase (NOS3) gene have been associated with high blood pressure levels, but not with resistant hypertension. The aim of the present study was to investigate if the -786T>C and G894T (Glu298Asp) polymorphisms of the NOS3 gene were associated with resistant hypertension.en_US
dc.description.abstract[Methods]: A prospective case-control observational study was performed. From a series of 950 consecutive patients followed up during 42 months, 48 patients with resistant hypertension were detected. 232 patients with controlled high blood pressure were also included.en_US
dc.description.abstract[Results]: No differences were observed in the distribution of G894T (Glu298Asp) NOS3 genotypes between the resistant hypertension group and the controlled hypertension patients. However, genotype -786CC was more frequent in the group of patients with resistant hypertension (33.3%) than in the group of patients with controlled high blood pressure (17.7%) (p 0.03). Furthermore carriers of allele T (-786TC and -786TT) were more frequent in patients with controlled hypertension (82.3%) than those with resistant hypertension (66.7%) (Multivariate analysis; RR 2.09; 95% CI 1.03–4.24; p 0.004).en_US
dc.description.abstract[Conclusion]: Our results indicate that genotype -786CC of the NOS3 gene increase the susceptibility to suffer resistant hypertension, which suggest that resistance to conventional therapy could be determined at the endothelial level.en_US
dc.format.extent259768 bytes-
dc.format.mimetypeapplication/pdf-
dc.language.isoengen_US
dc.publisherBioMed Centralen_US
dc.relation.isversionofPublisher's version-
dc.rightsopenAccessen_US
dc.titleAssociation between -T786C NOS3 polymorphism and resistant hypertension: a prospective cohort studyen_US
dc.typeartículoen_US
dc.identifier.doi10.1186/1471-2261-9-35-
dc.description.peerreviewedPeer revieweden_US
dc.relation.publisherversionhttp://dx.doi.org/10.1186/1471-2261-9-35en_US
dc.identifier.pmid19650939-
dc.type.coarhttp://purl.org/coar/resource_type/c_6501es_ES
item.fulltextWith Fulltext-
item.languageiso639-1en-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.openairetypeartículo-
item.cerifentitytypePublications-
item.grantfulltextopen-
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