Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/17414
COMPARTIR / EXPORTAR:
SHARE CORE BASE | |
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Título: | Association between -T786C NOS3 polymorphism and resistant hypertension: a prospective cohort study |
Autor: | Cruz-González, Ignacio; González-Sarmiento, Rogelio CSIC ORCID | Fecha de publicación: | 4-ago-2009 | Editor: | BioMed Central | Citación: | BMC Cardiovascular Disorders 9: 35 (2009) | Resumen: | [Background]: It is estimated that 5% of the hypertensive patients are resistant to conventional antihypertensive therapy. Polymorphisms in the endothelial nitric oxide synthase (NOS3) gene have been associated with high blood pressure levels, but not with resistant hypertension. The aim of the present study was to investigate if the -786T>C and G894T (Glu298Asp) polymorphisms of the NOS3 gene were associated with resistant hypertension. [Methods]: A prospective case-control observational study was performed. From a series of 950 consecutive patients followed up during 42 months, 48 patients with resistant hypertension were detected. 232 patients with controlled high blood pressure were also included. [Results]: No differences were observed in the distribution of G894T (Glu298Asp) NOS3 genotypes between the resistant hypertension group and the controlled hypertension patients. However, genotype -786CC was more frequent in the group of patients with resistant hypertension (33.3%) than in the group of patients with controlled high blood pressure (17.7%) (p 0.03). Furthermore carriers of allele T (-786TC and -786TT) were more frequent in patients with controlled hypertension (82.3%) than those with resistant hypertension (66.7%) (Multivariate analysis; RR 2.09; 95% CI 1.03–4.24; p 0.004). [Conclusion]: Our results indicate that genotype -786CC of the NOS3 gene increase the susceptibility to suffer resistant hypertension, which suggest that resistance to conventional therapy could be determined at the endothelial level. |
Descripción: | 6 páginas, 3 tablas.-- This is an Open Access article distributed under the terms of the Creative Commons Attribution License.-- et al. | Versión del editor: | http://dx.doi.org/10.1186/1471-2261-9-35 | URI: | http://hdl.handle.net/10261/17414 | DOI: | 10.1186/1471-2261-9-35 | ISSN: | 1471-2261 |
Aparece en las colecciones: | (IBMCC) Artículos |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
1471-2261-9-35.pdf | 426,87 kB | Adobe PDF | Visualizar/Abrir |
CORE Recommender
PubMed Central
Citations
7
checked on 15-abr-2024
SCOPUSTM
Citations
27
checked on 21-abr-2024
WEB OF SCIENCETM
Citations
19
checked on 24-feb-2024
Page view(s)
354
checked on 24-abr-2024
Download(s)
362
checked on 24-abr-2024
Google ScholarTM
Check
Altmetric
Altmetric
Artículos relacionados:
NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.