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Title

Absence of protection from West Nile virus disease and adverse effects in red legged partridges after non-structural NS1 protein administration

AuthorsRebollo, Belén; Llorente, Francisco; Pérez-Ramírez, Elisa ; Sarraseca, Javier; Gallardo, Carmina; Risalde, María Ángeles; Höfle, Ursula ; Figuerola, Jordi ; Soriguer, Ramón C. ; Venteo, Ángel; Jiménez Clavero, Miguel A.
KeywordsFlavivirus
Avian
Adverse effects
Immunization
NS1
Red-legged partridge
West Nile virus
In-vivo
Issue Date2018
PublisherElsevier
CitationComparative Immunology, Microbiology and Infectious Diseases 56: 30-33 (2018)
AbstractThe red-legged partridge (Alectoris rufa) is a competent host for West Nile virus (WNV) replication and highly susceptible to WNV disease. With the aim to assess in this species whether the inoculation of non-structural protein NS1 from WNV elicits a protective immune response against WNV infection, groups of partridges were inoculated with recombinant NS1 (NS1 group) or an unrelated recombinant protein (mock group), and challenged with infectious WNV. A third group received no inoculation prior to challenge (challenge group). The NS1 group failed to elicit detectable antibodies to NS1 while in the mock group a specific antibody response was observed. Moreover, no protection against WNV disease was observed in the NS1 group, but rather, it showed significantly higher viral RNA load and delayed neutralizing antibody response, and suffered a more severe clinical disease, which resulted in higher mortality. This adverse effect has not been observed before and warrants further investigations.
URIhttp://hdl.handle.net/10261/174113
Identifiersdoi: 10.1016/j.cimid.2017.12.006
e-issn: 1878-1667
issn: 0147-9571
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(EBD) Artículos
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