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Título: | Blimp-1 mediates tracheal lumen maturation in drosophila melanogaster |
Autor: | Öztürk-Çolak, Arzu CSIC; Stephan-Otto Attolini, Camille; Casanova, Jordi CSIC ORCID ; Araújo, Sofia J. | Palabras clave: | Blimp-1 Drosophila Trachea Chitin Btk29A AECM |
Fecha de publicación: | 4-oct-2018 | Editor: | Genetics Society of America | Citación: | Genetics 210(2): 653-663 (2018) | Resumen: | The specification of tissue identity during embryonic development requires precise spatio-temporal coordination of gene expression. Many transcription factors required for the development of organs have been identified and their expression patterns are known; however, the mechanisms through which they coordinate gene expression in time remain poorly understood. Here, we show that hormone-induced transcription factor Blimp-1 participates in the temporal coordination of tubulogenesis in Drosophila melanogaster by regulating the expression of many genes involved in tube maturation. In particular, we demonstrate that Blimp-1 regulates the expression of genes involved in chitin deposition and F-actin organization. We show that Blimp-1 is involved in the temporal control of lumen maturation by regulating the beginning of chitin deposition. We also report that Blimp-1 represses a variety of genes involved in tracheal maturation. Finally, we reveal that the kinase Btk29A serves as a link between Blimp-1 transcriptional repression and apical extracellular matrix organization. | Versión del editor: | https://doi.org/10.1534/genetics.118.301444 | URI: | http://hdl.handle.net/10261/174007 | DOI: | 10.1534/genetics.118.301444 | ISSN: | 0016-6731 | E-ISSN: | 1943-2631 |
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