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Title

High-resolution mapping of infraslow cortical brain activity enabled by graphene microtransistors

AuthorsMasvidal Codina, Eduard ; Illa, Xavi; Dasilva, Miguel; Bonaccini Calia, Andrea; Dragojević, Tanja; Vidal Rosas, Ernesto E.; Prats Alfonso, Elisabet; Martínez Aguilar, Javier; De la Cruz, Jose M.; Garcia Cortadella, Ramon; Godignon, Philippe; Rius, Gemma; Camassa, Alessandra; Del Corro, Elena; Bousquet, Jessica; Hébert, Clement; Durduran, Turgut; Villa, Rosa; Sanchez Vives, Maria V.; Garrido, Jose A.; Guimerà-Brunet, Anton
KeywordsGrafeno
Cerebro
Issue Date31-Dec-2018
PublisherSpringer Nature
CitationNature Materials 18: 280–288 (2018)
AbstractRecording infraslow brain signals (<0.1 Hz) with microelectrodes is severely hampered by current microelectrode materials, primarily due to limitations resulting from voltage drift and high electrode impedance. Hence, most recording systems include high-pass filters that solve saturation issues but come hand in hand with loss of physiological and pathological information. In this work, we use flexible epicortical and intracortical arrays of graphene solution-gated field-effect transistors (gSGFETs) to map cortical spreading depression in rats and demonstrate that gSGFETs are able to record, with high fidelity, infraslow signals together with signals in the typical local field potential bandwidth. The wide recording bandwidth results from the direct field-effect coupling of the active transistor, in contrast to standard passive electrodes, as well as from the electrochemical inertness of graphene. Taking advantage of such functionality, we envision broad applications of gSGFET technology for monitoring infraslow brain activity both in research and in the clinic.
Publisher version (URL)https://doi.org/10.1038/s41563-018-0249-4
URIhttp://hdl.handle.net/10261/173773
DOI10.1038/s41563-018-0249-4
ISSN1476-1122
E-ISSN1476-4660
Appears in Collections:(CIN2) Artículos
(IMB-CNM) Artículos
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